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HLA-B27 antibody (AA 81-180) (Alexa Fluor 750)

HLA-B27 Reactivity: Human WB, IF (cc), IF (p) Host: Rabbit Polyclonal Alexa Fluor 750
Catalog No. ABIN5004734
  • Target See all HLA-B27 Antibodies
    HLA-B27 (HLA Class I Histocompatibility Antigen, B-27 alpha Chain (HLA-B27))
    Binding Specificity
    AA 81-180
    Reactivity
    Human
    Host
    • 19
    • 6
    Rabbit
    Clonality
    • 19
    • 6
    Polyclonal
    Conjugate
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This HLA-B27 antibody is conjugated to Alexa Fluor 750
    Application
    • 21
    • 12
    • 12
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Predicted Reactivity
    Human
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human HLA B27
    Isotype
    IgG
    Top Product
    Discover our top product HLA-B27 Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    HLA-B27 (HLA Class I Histocompatibility Antigen, B-27 alpha Chain (HLA-B27))
    Alternative Name
    HLA B27 (HLA-B27 Products)
    Synonyms
    AS antibody, HLAB antibody, SPDA1 antibody, major histocompatibility complex, class I, B antibody, HLA-B antibody
    Background

    Synonyms: HLA B27 HLA-B27, HLAB, Leukocyte antigen class I B, Lymphocyte antigen, Major histocompatibility complex class I B, SPDA1, 1B27_HUMAN.

    Background: Major histocompatibility complex (MHC) molecules form an integral part of the immune response system. They are cell-surface receptors that bind peptides and present them to T lymphocytes. Human leukocyte antigens (HLAs) are polymorphic members of the MHC family that are specifically involved in the presentation of antigens to the T cell receptor. There are two classes of HLA antigens: class I (HLA-A, HLA-B and HLA-C) and class II (HLA-D). Class I molecules are expressed in nearly all cells and play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum. The differential structural properties of MHC class I and class II molecules account for their respective roles in activating different populations of T lymphocytes. HLA-B encodes a membrane anchored heavy chain which hetero-dimerizes with a light chain (-2-Microglobulin) to form MHC-I. Polymorphisms yield hundreds of HLA-B alleles. The HLA-B27 allele appears with increased frequency in uveitis patients.

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