Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

TMPRSS6 antibody (AA 711-811) (Alexa Fluor 750)

TMPRSS6 Reactivity: Human WB, IF (cc), IF (p) Host: Rabbit Polyclonal Alexa Fluor 750
Catalog No. ABIN5006592
  • Target See all TMPRSS6 Antibodies
    TMPRSS6 (Transmembrane Protease, serine 6 (TMPRSS6))
    Binding Specificity
    • 14
    • 8
    • 8
    • 6
    • 5
    • 2
    • 1
    AA 711-811
    Reactivity
    • 45
    • 8
    • 8
    • 6
    • 6
    • 5
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 43
    • 2
    Rabbit
    Clonality
    • 45
    Polyclonal
    Conjugate
    • 13
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TMPRSS6 antibody is conjugated to Alexa Fluor 750
    Application
    • 39
    • 21
    • 12
    • 12
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Predicted Reactivity
    Human,Mouse,Rat,Dog,Cow,Chicken
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Matriptase 2
    Isotype
    IgG
    Top Product
    Discover our top product TMPRSS6 Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    TMPRSS6 (Transmembrane Protease, serine 6 (TMPRSS6))
    Alternative Name
    Matriptase 2 (TMPRSS6 Products)
    Synonyms
    IRIDA antibody, 1300008A22Rik antibody, transmembrane protease, serine 6 antibody, transmembrane serine protease 6 antibody, Tmprss6 antibody, TMPRSS6 antibody
    Background

    Synonyms: Matriptase-2, Matriptase2, Membrane type serine proteinase 2, MTSP 2, MTSP2, PVAE354, TMPRSS 6, TMPRSS6, TMPS6_HUMAN, TMSP 6, TMSP6, Transmembrane protease serine 6, Type II Membrane Serine Proteinase 6.

    Background: Serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. Can also activate urokinase-type plasminogen activator with low efficiency. May play a specialized role in matrix remodeling processes in liver. Required to sense iron deficiency. Overexpression suppresses activation of the HAMP promoter.Involvement in disease:Defects in TMPRSS6 are the cause of iron-refractory iron deficiency anemia (IRIDA), also known as hypochromic microcytic anemia with defect in iron metabolism or hereditary iron-handling disorder or pseudo-iron-deficiency anemia. Key features include congenital hypochromic microcytic anemia, very low mean corpuscular erythrocyte volume, low transferrin saturation, abnormal iron absorption characterized by no hematologic improvement following treatment with oral iron, and abnormal iron utilization characterized by a sluggish, incomplete response to parenteral iron.

    Gene ID
    164656
    Pathways
    Transition Metal Ion Homeostasis
You are here:
Support