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SHoc2/Sur8 antibody (N-Term)

SHOC2 Reactivity: Human, Mouse, Rat WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN500706
  • Target See all SHoc2/Sur8 (SHOC2) Antibodies
    SHoc2/Sur8 (SHOC2) (Leucine-rich repeat protein SHOC-2 (SHOC2))
    Binding Specificity
    • 15
    • 13
    • 9
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 42
    • 27
    • 20
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 42
    Rabbit
    Clonality
    • 42
    Polyclonal
    Conjugate
    • 14
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SHoc2/Sur8 antibody is un-conjugated
    Application
    • 38
    • 19
    • 13
    • 13
    • 6
    • 3
    • 3
    • 3
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificity
    This antibody detects SHOC2.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human, mouse, rat
    Purification
    Peptide affinity chromatography
    Immunogen
    SHOC2 antibody was raised against a 21 amino acid peptide near the amino terminus of human SHOC2.
    Isotype
    IgG
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    Discover our top product SHOC2 Primary Antibody
  • Application Notes
    ELISA. Western blot: 1-2 μg/mL. Immunohistochemistry on paraffin sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS containing 0.02 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C.
  • Target
    SHoc2/Sur8 (SHOC2) (Leucine-rich repeat protein SHOC-2 (SHOC2))
    Alternative Name
    SHOC2 (SHOC2 Products)
    Synonyms
    AU017287 antibody, Sur8 antibody, mKIAA0862 antibody, SIAA0862 antibody, SOC2 antibody, SUR8 antibody, si:ch211-159c12.3 antibody, si:ch211-197i12.3 antibody, zgc:152956 antibody, soc-2 (suppressor of clear) homolog (C. elegans) antibody, SHOC2 leucine-rich repeat scaffold protein antibody, SHOC2 leucine-rich repeat scaffold protein S homeolog antibody, SHOC2, leucine rich repeat scaffold protein antibody, Shoc2 antibody, shoc2.S antibody, SHOC2 antibody, shoc2 antibody
    Background
    SHOC2 protein participates in protein binding / transferase activity in the fibroblast growth factor receptor signaling pathway and Ras protein signal transduction. It is a widely expressed protein composed almost entirely of leucine-rich repeats (LRR), with a lysine-rich sequence at the amino terminus and cytoplasmically localized. SHOC2 acts as a positive modulator of the RAS-MAPK signaling cascade, which is elicited by EGL-15 and LET-23 and mediated by LET-60. SHOC2 together with protein phosphatase 1c (PP1c) forms a highly specific M-Ras effector complex and is essential for activation of the MAPK pathway by growth factors. Furthermore, in tumor cells with Ras gene mutations, inhibition of SHOC2 expression inhibits MAPK, but not PI3K activity. The SHOC2-PP1c holoenzyme provides an attractive therapeutic target for inhibition of the MAPK pathway in cancer. Recent studies show that aberrantly acquired N-myristoylation of SHOC2 causes human disease Noonan-like syndrome with loose anagen hair.Synonyms: KIAA0862, Leucine-rich repeat protein SHOC-2, Protein soc-2 homolog, Protein sur-8 homolog, SHOC-2, SOC2, SUR8
    Gene ID
    8036
    NCBI Accession
    NP_031399
    UniProt
    Q9UQ13
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