PIRT antibody (AA 51-137) (Alexa Fluor 750)

Catalog No. ABIN5008860

Product Details anti-PIRT Antibody (Alexa Fluor 750)

Target: PIRT (Phosphoinositide-Interacting Regulator of Transient Receptor Potential Channels (PIRT))

Binding Specificity: AA 51-137

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PIRT antibody is conjugated to Alexa Fluor 750

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PIRT

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for PIRT

Target: PIRT (Phosphoinositide-Interacting Regulator of Transient Receptor Potential Channels (PIRT))

Alternative Name: PIRT (PIRT Products)

Synonyms: A530088H08Rik antibody, RGD1565284 antibody, phosphoinositide interacting regulator of transient receptor potential channels antibody, phosphoinositide-interacting regulator of transient receptor potential channels antibody, PIRT antibody, Pirt antibody

Background:

Synonyms: hCG_1776018, Phosphoinositide interacting regulator of transient receptor potential channels , Phosphoinositide-interacting protein, Pirt, PIRT_HUMAN.

Background: PIRT is a 137 amino acid multi-pass membrane protein. Highly conserved among vertebrates, PIRT consists of two transmembrane domains and one putative C-terminal phosphoinositide-binding domain. Although PIRT is expressed in peripheral nervous system, with highest levels in dorsal root ganglion and trigeminal neurons, and lowest levels in sympathetic and enteric neurons, it is not expressed in spinal cord. PIRT is a required component of the VR1 complex, which positively regulates VR1, a sensor of both noxious heat and capsaicin. Correspondingly, PIRT knockout results in impaired responses to noxious heat and capsaicin exposure, while VR1 remains unaltered. The gene that encodes PIRT maps to human chromosome 17p13.1.