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CYTIP antibody (AA 1-100) (Alexa Fluor 750)

CYTIP Reactivity: Human WB, IF (cc), IF (p) Host: Rabbit Polyclonal Alexa Fluor 750
Catalog No. ABIN5009327
  • Target See all CYTIP Antibodies
    CYTIP (Cytohesin 1 Interacting Protein (CYTIP))
    Binding Specificity
    • 14
    • 3
    • 3
    • 1
    • 1
    • 1
    AA 1-100
    Reactivity
    • 23
    • 6
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 23
    • 1
    Rabbit
    Clonality
    • 24
    Polyclonal
    Conjugate
    • 11
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CYTIP antibody is conjugated to Alexa Fluor 750
    Application
    • 23
    • 12
    • 12
    • 6
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Predicted Reactivity
    Human,Mouse,Rat,Dog,Cow,Horse,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human PSCDBP/CYTIP
    Isotype
    IgG
    Top Product
    Discover our top product CYTIP Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    CYTIP (Cytohesin 1 Interacting Protein (CYTIP))
    Alternative Name
    PSCDBP/CYTIP (CYTIP Products)
    Synonyms
    B3-1 antibody, CASP antibody, CYBR antibody, CYTHIP antibody, HE antibody, PSCDBP antibody, A130053M09Rik antibody, AI462064 antibody, C80816 antibody, Cbp antibody, Cybr antibody, Pscdbp antibody, cytohesin 1 interacting protein antibody, CYTIP antibody, Cytip antibody, cytip antibody
    Background

    Synonyms: B31, CASP, Cbp HE, CYBR, CYTHIP, Cytip, CYTIP_HUMAN, Cytohesin binder and regulator, Cytohesin-associated scaffolding protein, Cytohesin-binding protein HE, Cytohesin-interacting protein, HE antibody Pleckstrin Homology Sec7 and Coiled-Coil Domains Binding Protein, Pleckstrin homology Sec7 and coiled-coil domains-binding protein.

    Background: CYTIP is a cytoplasmic protein that is involved in lymphocytic cell adhesion. Expressed primarily in hematopoetic cells, CYTIP regulates the activity of cytohesin-1 (an integrin-activating protein involved in cell adhesion) by mediating its recruitment to the leukocyte membrane. Through its ability to bind cytohesin-1, CYTIP is able to sequester it to the cytoplasm, thereby preventing cytohesin-1 translocation to lymphocytes and interrupting the flow of information in the cell adhesion pathway. CYTIP can be recruited from the cytoplasm to the membrane by leukocyte integrins which interact with CYTIP through its PDZ domain. After membrane translocation, CYTIP can be re-located to the cytoplasm via exposure to a phorbol ester. Additionally, CYTIP associates with SNX27 (sorting nexin 27) and helps to coordinate trafficking and signaling complexes. Up-regulation of CYTIP is observed in maturing dendritic cells, suggesting a possible role in developmentally-controlled cell adhesion.

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