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FEZF1 antibody (AA 199-280) (Alexa Fluor 680)

FEZF1 Reactivity: Human IF (cc), IF (p) Host: Rabbit Polyclonal Alexa Fluor 680
Catalog No. ABIN5012724
  • Target See all FEZF1 Antibodies
    FEZF1 (FEZ Family Zinc Finger 1 (FEZF1))
    Binding Specificity
    • 15
    • 14
    • 8
    • 4
    • 1
    • 1
    AA 199-280
    Reactivity
    • 36
    • 10
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 36
    Rabbit
    Clonality
    • 36
    Polyclonal
    Conjugate
    • 10
    • 4
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This FEZF1 antibody is conjugated to Alexa Fluor 680
    Application
    • 20
    • 18
    • 12
    • 12
    • 3
    • 3
    • 2
    • 1
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Predicted Reactivity
    Human,Mouse,Rat,Cow,Sheep,Pig,Horse
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human ZNF312B
    Isotype
    IgG
    Top Product
    Discover our top product FEZF1 Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    FEZF1 (FEZ Family Zinc Finger 1 (FEZF1))
    Alternative Name
    ZNF312B/FEZF1 (FEZF1 Products)
    Synonyms
    RGD1560480 antibody, fezf antibody, znf312b antibody, MGC145310 antibody, FEZ antibody, ZNF312B antibody, 3110069A13Rik antibody, Fez antibody, Zfp312-like antibody, fez-like antibody, fez antibody, fezf2 antibody, wu:fc29c05 antibody, wu:fc89h05 antibody, zgc:153730 antibody, Fez family zinc finger 1 antibody, FEZ family zinc finger 1 antibody, Fez family zinc finger protein 1 antibody, FEZ family zinc finger 1 S homeolog antibody, Fezf1 antibody, FEZF1 antibody, fezf1 antibody, Tsp_12536a antibody, Tsp_12536 antibody, fezf1.S antibody
    Background

    Synonyms: FEZ, FEZ family zinc finger 1, Fez family zinc finger protein 1, fez like, fezf1, FEZF1_HUMAN, Zinc finger protein 312 like, Zinc finger protein 312B.

    Background: Olfactory sensory neurons contain olfactory receptors, which are G protein-coupled receptor proteins that localize to the cilia and display affinity for and bind to a variety of odor molecules. Olfactory neurons send their axons from the olfactory epithelium to the olfactory bulb, which is covered by the CNS basal lamina. FEZF1 (Fez family zinc finger protein 1), also known as Forebrain Embryonic Zinc Finger and Zinc finger protein 312B, is a 475 amino acid nuclear protein that is expressed in the olfactory epithelium and hypothalamus of mice. In FEZF1-deficient mice, axons of olfactory neurons do not reach the olfactory bulb, suggesting that FEXF1 is required for the penetration of olfactory axons though the basal lamina before innervation of the olfactory bulb. When FEZF1 translocates to the nucleus, it induces KRAS overexpression, resulting in activation of ERK-signaling. Overexpression of FEZF1 leads to accelerated proliferation in cultured cells and increased tumor mass in mice. There are three isoforms of FEZF1 that are produced as a result of alternative splicing events.

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