FLT1 antibody (Fms-Related tyrosine Kinase 1 (Vascular Endothelial Growth Factor/vascular Permeability Factor Receptor)) (AA 27-687)

Details for Product anti-FLT1 Antibody No. ABIN5013028, Supplier: Log in to see
Antigen
  • FLT
  • FLT-1
  • VEGFR-1
  • VEGFR1
  • FLT1
  • flt1b
  • sFlt1
  • AI323757
  • Flt-1
  • fms related tyrosine kinase 1
  • FMS-related tyrosine kinase 1
  • vascular endothelial growth factor receptor 1
  • fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
  • FMS-like tyrosine kinase 1
  • FLT1
  • Flt1
  • CpipJ_CPIJ012087
  • flt1
Alternatives
anti-Human FLT1 antibody for Enzyme Immunoassay
Epitope
AA 27-687
43
33
17
16
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12
8
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2
2
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2
1
1
1
1
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Reactivity
Human
435
149
113
17
17
3
3
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2
2
2
2
2
1
1
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1
Host
Goat
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249
13
5
2
1
Clonality
Polyclonal
Conjugate
This FLT1 antibody is un-conjugated
35
20
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2
1
1
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1
Application
Blocking Reagent (BR), Cytometry by Time of Flight (CyTOF), Flow Cytometry (FACS), Immunohistochemistry (IHC), Western Blotting (WB)
305
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148
102
101
77
60
40
22
13
13
10
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3
2
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2
1
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1
Options
Supplier
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Supplier Product No.
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Immunogen S. frugiperda insect ovarian cell line Sf 21-derived recombinant human VEGF R1/Flt-1, Ser27-His687, Accession # NP_001153392
Isotype IgG
Specificity Detects human VEGF R1/Flt-1 in direct ELISAs and Western blots. In direct ELISAs, this antibody shows approximately 20 % cross-reactivity with recombinant mouse VEGF R1 and less than 10 % cross-reactivity with recombinant human (rh) VEGF R2 and rhVEGF R3.
Purification Immunogen affinity purified
Endotoxin Level <0.10 EU per 1 μg of the antibody by the LAL method.
Plasmids, Primers & others Plasmids, Primers & others FLT1 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name VEGF R1/Flt-1 (FLT1 Antibody Abstract)
Background Alternative Names: EC 2.7.10, EC 2.7.10.1, FLT, FLT1, FLT-1, Fms-like tyrosine kinase 1, fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascularpermeability factor receptor), FRT, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor FLT, vascular endothelial growth factor receptor 1, Vascular permeability factor receptor, VEGFR1, VEGFR-1
Gene ID 2321
NCBI Accession NP_001153392
Pathways RTK Signaling, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals
Application Notes Western Blot 0.1 μg/mL
Flow Cytometry 2.5 μg/10^6 cells
Immunohistochemistry 5-15 μg/mL
Blockade of Receptor-ligand Interaction
CyTOF-ready
Restrictions For Research Use only
Reconstitution Reconstitute at 0.2 mg/mL in sterile PBS.
Buffer Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Preservative Without preservative
Storage 4 °C,-20 °C,-80 °C
Storage Comment Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt,-20°C to -70°C as supplied. 1 month,2°C to 8°C under sterile conditions after reconstitution. 6 months,-20°C to -70°C under sterile conditions after reconstitution.
Expiry Date 12 months
Supplier Images
Immunohistochemistry (IHC) image for anti-Fms-Related tyrosine Kinase 1 (Vascular Endothelial Growth Factor/vascular Permeability Factor Receptor) (FLT1) (AA 27-687) antibody (ABIN5013028) VEGF R1/Flt-1 in Human Breast Cancer Tissue. VEGF R1/Flt-1 was detected in immersion ...
Immunohistochemistry (IHC) image for anti-Fms-Related tyrosine Kinase 1 (Vascular Endothelial Growth Factor/vascular Permeability Factor Receptor) (FLT1) (AA 27-687) antibody (ABIN5013028) VEGF R1/Flt-1 in Human Ovarian Cancer Tissue. VEGF R1/Flt-1 was detected in immersion...
Product cited in: Basavarajappa, Sulaiman, Qi, Shetty, Sheik Pran Babu, Sishtla, Lee, Quigley, Alkhairy, Briggs, Gupta, Tang, Shadmand, Grant, Boulton, Seo, Corson: "Ferrochelatase is a therapeutic target for ocular neovascularization." in: EMBO molecular medicine, Vol. 9, Issue 6, pp. 786-801, 2018 (PubMed). Method employed by authors: Western Blotting (WB), Western Blotting (WB) (Sample species: Human).

Spiel, Salahuddin, Pernicone, Zsengeller, Wang, Modest, Karumanchi, Hecht: "Placental soluble fms-like tyrosine kinase expression in small for gestational age infants and risk for adverse outcomes." in: Placenta, Vol. 52, pp. 10-16, 2018 (PubMed). Method employed by authors: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Sample species: Human).

Capossela, Bertolo, Gunasekera, Pötzel, Baur, Stoyanov: "VEGF vascularization pathway in human intervertebral disc does not change during the disc degeneration process." in: BMC research notes, Vol. 11, Issue 1, pp. 333, 2018 (PubMed). Method employed by authors: Western Blotting (WB) (Sample species: Cow (Bovine)).

Szalai, Romero, Chaiworapongsa, Xu, Wang, Ahn, Xu, Chiang, Sundell, Wang, Jiang, Plazyo, Olive, Tarca, Dong, Qureshi, Papp, Hassan, Hernandez-Andrade, Than: "Full-length human placental sFlt-1-e15a isoform induces distinct maternal phenotypes of preeclampsia in mice." in: PLoS ONE, Vol. 10, Issue 4, pp. e0119547, 2016 (PubMed). Method employed by authors: Western Blotting (WB), Western Blotting (WB) (Sample species: Human).

Kim, Kim, Kim, Cho, Lee: "The effect of vascular endothelial growth factor on osteoclastogenesis in rheumatoid arthritis." in: PLoS ONE, Vol. 10, Issue 4, pp. e0124909, 2016 (PubMed). Method employed by authors: Neutralization (Neut), Neutralization (Neut) (Sample species: Human).

Chanakira, Kir, Barke, Santilli, Ramakrishnan, Roy: "Hypoxia Differentially Regulates Arterial and Venous Smooth Muscle Cell Migration." in: PLoS ONE, Vol. 10, Issue 9, pp. e0138587, 2016 (PubMed). Method employed by authors: Neutralization (Neut), Neutralization (Neut) (Sample species: Human).

Shvartsman, Storrie-White, Lee, Kearney, Brudno, Ho, Cezar, McCann, Anderson, Koullias, Tapia, Vandenburgh, Lichtman, Mooney: "Sustained delivery of VEGF maintains innervation and promotes reperfusion in ischemic skeletal muscles via NGF/GDNF signaling." in: Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 22, Issue 7, pp. 1243-1253, 2015 (PubMed). Method employed by authors: Functional Studies (Func), Functional Studies (Func) (Sample species: Human).

Hou, Cheng, Chung, Kuo, Yeh, Chang, Lu, Wang, Yu: "Elastase induces lung epithelial cell autophagy through placental growth factor: a new insight of emphysema pathogenesis." in: Autophagy, Vol. 10, Issue 9, pp. 1509-21, 2015 (PubMed). Method employed by authors: Neutralization (Neut), Neutralization (Neut) (Sample species: Human).

Nevo, Lee, Caniggia: "Attenuation of VEGFR-2 expression by sFlt-1 and low oxygen in human placenta." in: PLoS ONE, Vol. 8, Issue 11, pp. e81176, 2014 (PubMed). Method employed by authors: Western Blotting (WB), Western Blotting (WB) (Sample species: Human).

Larson, Lee, Lezcano, Zhan, Huang, Fischer, Murphy: "Melanoma spheroid formation involves laminin-associated vasculogenic mimicry." in: The American journal of pathology, Vol. 184, Issue 1, pp. 71-8, 2014 (PubMed). Method employed by authors: Immunohistochemistry (IHC), Immunohistochemistry (IHC) (Sample species: Human).

Lezcano, Kleffel, Lee, Larson, Zhan, DoRosario, Wang, Schatton, Murphy: "Merkel cell carcinoma expresses vasculogenic mimicry: demonstration in patients and experimental manipulation in xenografts." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 94, Issue 10, pp. 1092-102, 2014 (PubMed). Method employed by authors: Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Frozen Sections) (IHC (fro)) (Sample species: Human).

Vizio, Biasi, Scirelli, Novarino, Prati, Ciuffreda, Montrucchio, Poli, Bellone: "Pancreatic-carcinoma-cell-derived pro-angiogenic factors can induce endothelial-cell differentiation of a subset of circulating CD34+ progenitors." in: Journal of translational medicine, Vol. 11, pp. 314, 2013 (PubMed). Method employed by authors: Blocking Peptide (BP), Blocking Peptide (BP) (Sample species: Human).

Cai, Chen, Ruan, Han, Liu, Qi, Boye, Hauswirth, Grant, Boulton: "γ-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1." in: The Journal of biological chemistry, Vol. 286, Issue 49, pp. 42514-23, 2012 (PubMed). Method employed by authors: Proximity Ligation Assay (PLA), Proximity Ligation Assay (PLA) (Sample species: Cow (Bovine)).

Munaut, Lorquet, Pequeux, Coulon, Le Goarant, Chantraine, Noël, Goffin, Tsatsaris, Subtil, Foidart: "Differential expression of Vegfr-2 and its soluble form in preeclampsia." in: PLoS ONE, Vol. 7, Issue 3, pp. e33475, 2012 (PubMed). Method employed by authors: Western Blotting (WB), Western Blotting (WB) (Sample species: Human).

Barsoum, Renaud, Graham: "Glyceryl trinitrate inhibits hypoxia-induced release of soluble fms-like tyrosine kinase-1 and endoglin from placental tissues." in: The American journal of pathology, Vol. 178, Issue 6, pp. 2888-96, 2011 (PubMed). Method employed by authors: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Sample species: Human).

Byeon, Lee, Choi, Lee, Lee, Chu, Kwon: "Vascular endothelial growth factor as an autocrine survival factor for retinal pigment epithelial cells under oxidative stress via the VEGF-R2/PI3K/Akt." in: Investigative ophthalmology & visual science, Vol. 51, Issue 2, pp. 1190-7, 2010 (PubMed). Method employed by authors: Immunocytochemistry (ICC), Immunocytochemistry (ICC) (Sample species: Human).

Lee, Myers, Kim: "Vascular endothelial growth factor drives autocrine epithelial cell proliferation and survival in chronic rhinosinusitis with nasal polyposis." in: American journal of respiratory and critical care medicine, Vol. 180, Issue 11, pp. 1056-67, 2009 (PubMed). Method employed by authors: Neutralization (Neut), Neutralization (Neut) (Sample species: Human).

Akintoye, Lam, Shi, Brahim, Collins, Robey: "Skeletal site-specific characterization of orofacial and iliac crest human bone marrow stromal cells in same individuals." in: Bone, Vol. 38, Issue 6, pp. 758-68, 2007 (PubMed). Method employed by authors: Immunocytochemistry (ICC), Immunocytochemistry (ICC) (Sample species: Human).

Ball, Shuttleworth, Kielty: "Vascular endothelial growth factor can signal through platelet-derived growth factor receptors." in: The Journal of cell biology, Vol. 177, Issue 3, pp. 489-500, 2007 (PubMed). Method employed by authors: Neutralization (Neut), Neutralization (Neut) (Sample species: Human).

Getmanova, Chen, Bloom, Gokemeijer, Shamah, Warikoo, Wang, Ling, Sun: "Antagonists to human and mouse vascular endothelial growth factor receptor 2 generated by directed protein evolution in vitro." in: Chemistry & biology, Vol. 13, Issue 5, pp. 549-56, 2006 (PubMed). Method employed by authors: Flow Cytometry (FACS), Flow Cytometry (FACS) (Sample species: Human).

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