Caspase 12 antibody (AA 100-321)

Catalog No. ABIN5027075

Product Details anti-Caspase 12 Antibody

Target: Caspase 12 (CASP12) (Caspase 12 (Gene/pseudogene) (CASP12))

Binding Specificity: AA 100-321

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Caspase 12 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Protein A Chromatography

Immunogen: A partial length recombinant Caspase-12 protein (amino acids 100-321) was used as the immunogen for this antibody.

Isotype: IgG

Application Details

Application Notes: WB: 4-6 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Target Details for Caspase 12

Target: Caspase 12 (CASP12) (Caspase 12 (Gene/pseudogene) (CASP12))

Alternative Name: Caspase-12 (CASP12 Products)

Synonyms: Caspase-12 antibody, CASP-12 antibody, CASP12P1 antibody, caspase 12 antibody, caspase 12 (gene/pseudogene) antibody, Casp12 antibody, CASP12 antibody

Background: Caspase 12 belongs to a family of enzymes called caspases that is highly related to members of the ICE subfamily. Other caspases cleave their substrates at C-terminal aspartic acid residue but caspase 12 does not have protease properties rather it processes inflammatory cytokines. It is involved in the activation cascade of caspases responsible for apoptosis execution. Diseases associated with CASP12 include sepsis and prion disease. Caspase 12 is mainly expressed in skeletal muscle and lung.

Molecular Weight: 27 kDa

Gene ID: 101000000

UniProt: Q6UXS9

Pathways: Apoptosis, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response