IL-37 antibody

Catalog No. ABIN5027737

Product Details anti-IL-37 Antibody

Target: IL-37 (IL37) (Interleukin 37 (IL37))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL-37 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Protein A Chromatography

Immunogen: Full length recombinant IL-37 protein was used as the immunogen for this antibody.

Isotype: IgG

Application Details

Application Notes: WB: 2-4 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Target Details for IL-37

Target: IL-37 (IL37) (Interleukin 37 (IL37))

Alternative Name: IL-37 (IL37 Products)

Synonyms: FIL1 antibody, FIL1(ZETA) antibody, FIL1Z antibody, IL-1F7 antibody, IL-1H antibody, IL-1H4 antibody, IL-1RP1 antibody, IL-37 antibody, IL1F7 antibody, IL1H4 antibody, IL1RP1 antibody, interleukin 37 antibody, IL37 antibody

Background: IL-37 (Interleukin-37) is a member of IL-1 family and is primarily an anti-inflammatory cytokine, which reduces systemic and local inflammation. There are five different splice variants of IL-37 termed IL-37a-e, where Isoform IL-37b is the largest isoform. IL-37 has significant sequence similarity with IL-18 and highly expressed in inflammatory tissues, which inhibits the excessive inflammatory response. The expression is highly induced by several toll-like receptor (TLR) ligands and pro-inflammatory cytokines such as IL-1beta, TNF-alpha, IFN-gamma. IL-37 is a potent inhibitor of innate immunity by shifting the cytokine equilibrium away from excessive inflammation.

Molecular Weight: 20 kDa

Gene ID: 27178

UniProt: Q9NZH6