Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

SQSTM1 antibody (AA 335-345) (PE)

SQSTM1 Reactivity: Human WB Host: Rabbit Polyclonal PE
Catalog No. ABIN5066117
  • Target See all SQSTM1 Antibodies
    SQSTM1 (Sequestosome 1 (SQSTM1))
    Binding Specificity
    • 19
    • 17
    • 15
    • 13
    • 11
    • 10
    • 8
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 335-345
    Reactivity
    • 171
    • 64
    • 61
    • 18
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 145
    • 24
    • 1
    • 1
    Rabbit
    Clonality
    • 144
    • 27
    Polyclonal
    Conjugate
    • 78
    • 13
    • 12
    • 8
    • 8
    • 7
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This SQSTM1 antibody is conjugated to PE
    Application
    • 121
    • 58
    • 50
    • 40
    • 25
    • 23
    • 18
    • 16
    • 14
    • 13
    • 10
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Specificity
    Ubiquitously expressed.,Detects ~60 kDa. Band at 40 kDa is isoform 2.
    Cross-Reactivity
    Human, Mouse
    Purification
    Peptide Affinity Purified
    Immunogen
    Synthetic peptide from the C-terminal of Human SQSTM1 (aa. 335-345)
    Isotype
    IgG
    Top Product
    Discover our top product SQSTM1 Primary Antibody
  • Application Notes
    • WB (1:1000)
    • optimal dilutions for assays should be determined by the user.
    Comment

    A 1:1000 dilution of ABIN5066117 was sufficient for detection of SQSTM1 in 15 μg of Human HeLa Cell Lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Conjugated antibodies should be stored at 4°C
  • Target
    SQSTM1 (Sequestosome 1 (SQSTM1))
    Alternative Name
    SQSTM1 (SQSTM1 Products)
    Synonyms
    SQSTM1 antibody, sqstm1 antibody, MGC79491 antibody, A170 antibody, OSIL antibody, PDB3 antibody, ZIP3 antibody, p60 antibody, p62 antibody, p62B antibody, OSF-6 antibody, Osi antibody, STAP antibody, ZIP antibody, sb:cb621 antibody, zgc:85784 antibody, sequestosome 1 antibody, sequestosome 1 L homeolog antibody, SQSTM1 antibody, sqstm1 antibody, Sqstm1 antibody, sqstm1.L antibody
    Background
    SQSTM1 or Sequestome 1 (p62) is a ubiquitin binding protein that interacts with ubiqutin, providing a scaffold for several signaling proteins and triggering degradation of proteins throught the proteasome or lysossome. This gene regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Mutations in this gene result in sporadic and familial Paget disease of bone. SQSTM1 also binds autophagosomal membrane protein LC3/ATG8.
    Gene ID
    8878
    NCBI Accession
    NP_001135770
    UniProt
    Q13501
    Pathways
    NF-kappaB Signaling, Neurotrophin Signaling Pathway, Autophagy
You are here:
Support