TRF2 antibody

Catalog No. ABIN531975

Product Details anti-TRF2 Antibody

Target: TRF2 (TERF2) (Telomeric Repeat Binding Factor 2 (TERF2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TRF2 antibody is un-conjugated

Application: ELISA, Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))

Purpose: Mouse monoclonal antibody raised against full length recombinant TERF2.

Cross-Reactivity: Deer, Human, Mouse, Rat

Immunogen: Recombinant protein corresponding to full length human TERF2.

Clone: 4A794-15

Isotype: IgG1

Application Details

Application Notes: The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In PBS (0.05 % BSA, 0.05 % sodium azide)

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.

References for anti-TRF2 antibody (ABIN531975)

Zhang, Zhang, Miao, Ding: "The telomeric protein TRF2 is critical for the protection of A549 cells from both telomere erosion and DNA double-strand breaks driven by salvicine." in: Molecular pharmacology, Vol. 73, Issue 3, pp. 824-32, (2008) (PubMed).

Muramatsu, Tahara, Ono, Tsuruo, Seimiya: "Telomere elongation by a mutant tankyrase 1 without TRF1 poly(ADP-ribosyl)ation." in: Experimental cell research, Vol. 314, Issue 5, pp. 1115-24, (2008) (PubMed).

Biroccio, Rizzo, Elli, Koering, Belleville, Benassi, Leonetti, Stevens, DIncalci, Zupi, Gilson: "TRF2 inhibition triggers apoptosis and reduces tumourigenicity of human melanoma cells." in: European journal of cancer (Oxford, England : 1990), Vol. 42, Issue 12, pp. 1881-8, (2006) (PubMed).

Raz, Carlotti, Vermolen, van der Poel, Sloos, Knaän-Shanzer, de Vries, Hoeben, Young, Tanke, Garini, Dirks: "Changes in lamina structure are followed by spatial reorganization of heterochromatic regions in caspase-8-activated human mesenchymal stem cells." in: Journal of cell science, Vol. 119, Issue Pt 20, pp. 4247-56, (2006) (PubMed).

Barcaroli, Bongiorno-Borbone, Terrinoni, Hofmann, Rossi, Knight, Matera, Melino, De Laurenzi: "FLASH is required for histone transcription and S-phase progression." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 40, pp. 14808-12, (2006) (PubMed).

Target Details for TRF2

Target: TRF2 (TERF2) (Telomeric Repeat Binding Factor 2 (TERF2))

Alternative Name: TERF2 (TERF2 Products)

Synonyms: TERF2 antibody, TRBF2 antibody, TRF2 antibody, trf2 antibody, telomeric repeat binding factor 2 antibody, telomeric repeat binding factor 2 L homeolog antibody, TERF2 antibody, Terf2 antibody, terf2.L antibody

Gene ID: 7014

Pathways: Cell Division Cycle, Telomere Maintenance