TLR3 antibody (AA 55-85)

Catalog No. ABIN531989

Product Details anti-TLR3 Antibody

Target: TLR3 (Toll-Like Receptor 3 (TLR3))

Binding Specificity: AA 55-85

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TLR3 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Mouse monoclonal antibody raised against synthetic peptide of TLR3.

Cross-Reactivity: Human

Immunogen: A synthetic peptide corresponding to amino acids 55-85 of human TLR3.

Clone: 40C1285-6

Isotype: IgG1

Application Details

Application Notes: The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In PBS (0.05 % BSA, 0.05 % sodium azide)

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.

References for anti-TLR3 antibody (ABIN531989)

Güttsches, Jacobsen, Theiss, Rittig, Rehimi, Kley, Vorgerd, Steinstraesser: "Human ?-defensin-3 correlates with muscle fibre degeneration in idiopathic inflammatory myopathies." in: Innate immunity, Vol. 20, Issue 1, pp. 49-60, (2013) (PubMed).

Heutinck, Kassies, Florquin, ten Berge, Hamann, Rowshani: "SerpinB9 expression in human renal tubular epithelial cells is induced by triggering of the viral dsRNA sensors TLR3, MDA5 and RIG-I." in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, Vol. 27, Issue 7, pp. 2746-54, (2012) (PubMed).

Heutinck, Rowshani, Kassies, Claessen, van Donselaar-van der Pant, Bemelman, Eldering, van Lier, Florquin, Ten Berge, Hamann: "Viral double-stranded RNA sensors induce antiviral, pro-inflammatory, and pro-apoptotic responses in human renal tubular epithelial cells." in: Kidney international, Vol. 82, Issue 6, pp. 664-75, (2012) (PubMed).

Kim, Yang, Lee, Kim, Shin, Park, Choi, Kim, Choi: "Double-stranded RNA mediates interferon regulatory factor 3 activation and interleukin-6 production by engaging Toll-like receptor 3 in human brain astrocytes." in: Immunology, Vol. 124, Issue 4, pp. 480-8, (2008) (PubMed).

Wong, Cheung, Ip, Lam: "Intracellular signaling mechanisms regulating toll-like receptor-mediated activation of eosinophils." in: American journal of respiratory cell and molecular biology, Vol. 37, Issue 1, pp. 85-96, (2007) (PubMed).

Ranjith-Kumar, Miller, Sun, Xiong, Santos, Yarbrough, Lamb, Mills, Duffy, Hoose, Cunningham, Holzenburg, Mbow, Sarisky, Kao: "Effects of single nucleotide polymorphisms on Toll-like receptor 3 activity and expression in cultured cells." in: The Journal of biological chemistry, Vol. 282, Issue 24, pp. 17696-705, (2007) (PubMed).

Lundberg, Drexler, Monaco, Williams, Sacre, Feldmann, Foxwell: "Key differences in TLR3/poly I:C signaling and cytokine induction by human primary cells: a phenomenon absent from murine cell systems." in: Blood, Vol. 110, Issue 9, pp. 3245-52, (2007) (PubMed).

Morikawa, Sugiyama, Kume, Ota, Kashima, Tomita, Kitamura, Kodama, Fukayama, Aburatani: "Identification of Toll-like receptor 3 as a potential therapeutic target in clear cell renal cell carcinoma." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 13, Issue 19, pp. 5703-9, (2007) (PubMed).

Target Details for TLR3

Target: TLR3 (Toll-Like Receptor 3 (TLR3))

Alternative Name: CD283 / TLR3 (TLR3 Products)

Synonyms: CD283 antibody, IIAE2 antibody, AI957183 antibody, zgc:123006 antibody, toll like receptor 3 antibody, toll-like receptor 3 antibody, TLR3 antibody, Tlr3 antibody, tlr3 antibody

Gene ID: 7098

Pathways: TLR Signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades