Geminin antibody (AA 1-209)

Catalog No. ABIN532939

Product Details anti-Geminin Antibody

Target: Geminin (GMNN) (Geminin, DNA Replication Inhibitor (GMNN))

Binding Specificity: AA 1-209

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Geminin antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purpose: Mouse monoclonal antibody raised against full length recombinant GMNN.

Cross-Reactivity: Human

Immunogen: Recombinant protein corresponding to amino acids 1-209 of human GMNN.

Clone: 2H7

Isotype: IgG1

Application Details

Application Notes: Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In PBS, pH 7.4 (10 % glycerol, 0.02 % sodium azide).

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing.

References for anti-Geminin antibody (ABIN532939)

Tsunematsu, Takihara, Ishimaru, Pagano, Takata, Kudo: "Aurora-A controls pre-replicative complex assembly and DNA replication by stabilizing geminin in mitosis." in: Nature communications, Vol. 4, pp. 1885, (2013) (PubMed).

Pitulescu, Kessel, Luo: "The regulation of embryonic patterning and DNA replication by geminin." in: Cellular and molecular life sciences : CMLS, Vol. 62, Issue 13, pp. 1425-33, (2005) (PubMed).

Luo, Yang, Takihara, Knoetgen, Kessel: "The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions." in: Nature, Vol. 427, Issue 6976, pp. 749-53, (2004) (PubMed).

Target Details for Geminin

Target: Geminin (GMNN) (Geminin, DNA Replication Inhibitor (GMNN))

Alternative Name: Geminin (GMNN Products)

Synonyms: CG3183 antibody, Dm Geminin antibody, Dm geminin antibody, Dmel\\CG3183 antibody, Gem antibody, Geminin antibody, anon-WO0257455.1 antibody, gem antibody, l(2)k14019 antibody, v(2)k09107 antibody, sb:cb254 antibody, zgc:66217 antibody, GB16871 antibody, GMNN antibody, geminin antibody, dyak_GLEANR_833 antibody, DyakGE24654 antibody, GE24654 antibody, LOC100049517 antibody, AW546347 antibody, geminin, DNA replication inhibitor antibody, CG3183 gene product from transcript CG3183-RA antibody, geminin antibody, GE24654 gene product from transcript GE24654-RA antibody, GMNN antibody, geminin antibody, gmnn antibody, LOC410093 antibody, Dyak\geminin antibody, Gmnn antibody

Gene ID: 51053

NCBI Accession: NM_015895

Pathways: EGFR Signaling Pathway, DNA Replication