SHP1 antibody (C-Term)

Catalog No. ABIN533154

Product Details anti-SHP1 Antibody

Target: SHP1 (PTPN6) (Protein-tyrosine Phosphatase 1C (PTPN6))

Binding Specificity: C-Term

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SHP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunoprecipitation (IP)

Purpose: Mouse monoclonal antibody raised against partial recombinant PTPN6.

Specificity: This sequence is highly conserved in rat and mouse SHP1.

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: Recombinant protein corresponding to C-terminus of human PTPN6.

Clone: M160

Isotype: IgG1

Application Details

Application Notes: ELISA (1:2000)
Immunocytochemistry (1:100)
Immunoprecipitation (5-10 µL)
Western Blot (1:500)
The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In PBS (50 % glycerol, 1 mg/mL BSA, 0.05 % sodium azide)

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C.
Aliquot to avoid repeated freezing and thawing.

References for anti-SHP1 antibody (ABIN533154)

Jones, Craik, Gibbins, Poole: "Regulation of SHP-1 tyrosine phosphatase in human platelets by serine phosphorylation at its C terminus." in: The Journal of biological chemistry, Vol. 279, Issue 39, pp. 40475-83, (2004) (PubMed).

Zhang, Shen, Lu, Cole: "The role of C-terminal tyrosine phosphorylation in the regulation of SHP-1 explored via expressed protein ligation." in: The Journal of biological chemistry, Vol. 278, Issue 7, pp. 4668-74, (2003) (PubMed).

Zhang, Somani, Siminovitch: "Roles of the SHP-1 tyrosine phosphatase in the negative regulation of cell signalling." in: Seminars in immunology, Vol. 12, Issue 4, pp. 361-78, (2000) (PubMed).

Target Details for SHP1

Target: SHP1 (PTPN6) (Protein-tyrosine Phosphatase 1C (PTPN6))

Alternative Name: PTPN6 (PTPN6 Products)

Synonyms: HCPH antibody, HPTP1C antibody, PTP-1C antibody, SH-PTP1 antibody, SHP-1 antibody, SHP-1L antibody, SHP1 antibody, DRPLA antibody, Hcph antibody, Ptp1C antibody, me antibody, motheaten antibody, Ptph6 antibody, Shp-1 antibody, fj22f05 antibody, wu:fj22f05 antibody, zgc:55501 antibody, ptpn6 antibody, protein tyrosine phosphatase, non-receptor type 6 antibody, protein tyrosine phosphatase, non-receptor type 6 L homeolog antibody, PTPN6 antibody, Ptpn6 antibody, ptpn6 antibody, ptpn6.L antibody

Gene ID: 5777

Pathways: JAK-STAT Signaling, TCR Signaling, TLR Signaling, Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, BCR Signaling