CD147 antibody

Catalog No. ABIN535271

Product Details anti-CD147 Antibody

Target: CD147 (BSG) (Basigin (Ok Blood Group) (BSG))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD147 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Mouse monoclonal antibody raised against recombinant BSG.

Specificity: This antibody recognizes extracellular Ig domain D1 of BSG (Neurothelin), a 50-60 KDa type I transmembrane glycoprotein primarily expressed on all leukocytes, redblood cells, platelets and endothelial cells, it is not expressed by resting lymphocytes. This antibody is a high-affinity antibody capable of binding to unstimulated peripheral blood T cells.

Cross-Reactivity: Human, Pig

Immunogen: Recombinant protein corresponding to human BSG.

Clone: MEM-M6-2

Isotype: IgG2b

Application Details

Application Notes: Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (10 μg/mL)
The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In PBS, pH 7.4 (0.09 % sodium azide)

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 4°C. Do not freeze.
Aliquot to avoid repeated freezing and thawing.

References for anti-CD147 antibody (ABIN535271)

Schmidt, Bültmann, Fischel, Gillitzer, Cullen, Walch, Jost, Ungerer, Tolley, Lindemann, Gawaz, Schömig, May: "Extracellular matrix metalloproteinase inducer (CD147) is a novel receptor on platelets, activates platelets, and augments nuclear factor kappaB-dependent inflammation in monocytes." in: Circulation research, Vol. 102, Issue 3, pp. 302-9, (2008) (PubMed).

Melchior, Denys, Deligny, Mazurier, Allain: "Cyclophilin B induces integrin-mediated cell adhesion by a mechanism involving CD98-dependent activation of protein kinase C-delta and p44/42 mitogen-activated protein kinases." in: Experimental cell research, Vol. 314, Issue 3, pp. 616-28, (2008) (PubMed).

Ruiz, Castro-Castro, Bustelo: "CD147 inhibits the nuclear factor of activated T-cells by impairing Vav1 and Rac1 downstream signaling." in: The Journal of biological chemistry, Vol. 283, Issue 9, pp. 5554-66, (2008) (PubMed).

Target Details for CD147

Target: CD147 (BSG) (Basigin (Ok Blood Group) (BSG))

Alternative Name: CD147 (BSG Products)

Synonyms: EMMPRIN antibody, RPE7 antibody, 5F7 antibody, CD147 antibody, M6 antibody, OK antibody, TCSF antibody, AI115436 antibody, AI325119 antibody, HT-7 antibody, 5A11 antibody, CE9 antibody, HT7 antibody, Ox47R antibody, basignin antibody, wu:fb26a05 antibody, wu:fo98e12 antibody, bsg antibody, prso03 antibody, basigin (Ok blood group) antibody, basigin antibody, basigin (Ok blood group) S homeolog antibody, BSG antibody, Bsg antibody, bsg antibody, bsg.S antibody

Gene ID: 682

Pathways: S100 Proteins