CD44 antibody

Catalog No. ABIN535461

Product Details anti-CD44 Antibody

Target: CD44

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD44 antibody is un-conjugated

Application: Flow Cytometry (FACS), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Immunoprecipitation (IP)

Purpose: Mouse monoclonal antibody raised against native CD44.

Specificity: This antibody reacts with extracellular (N-terminal) domain of standard CD44(Phagocyte glycoprotein 1), a 80-95 KDa transmembrane glycoprotein (hyaladherin family) present on the most of cells and tissues (leukocytes, endothelial cells, mesenchymal cells,etc.), it is negative on platelets and hepatocytes.

Cross-Reactivity: Dog, Human, Pig

Immunogen: Native purified CD44 from African Green Monkey COS-7 cells.

Clone: MEM-263

Isotype: IgG1

Application Details

Application Notes: Western Blot (2 μg/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (10 μg/mL)
The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: In PBS, pH 7.4 (0.09 % sodium azide)

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 4°C. Do not freeze.

References for anti-CD44 antibody (ABIN535461)

Qin, Yang, Xu, Smithc, Xu, Yuan, Li: "Concurrent CD44s and STAT3 expression in human clear cell renal cellular carcinoma and its impact on survival." in: International journal of clinical and experimental pathology, Vol. 7, Issue 6, pp. 3235-44, (2014) (PubMed).

Li, Tang, Wu, Karnak, Meng, Thompson, Hao, Li, Qiao, Lin, Fuchs, Simeone, Chen, Lawrence, Xu: "HAb18G/CD147 promotes pSTAT3-mediated pancreatic cancer development via CD44s." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 19, Issue 24, pp. 6703-15, (2013) (PubMed).

Subramaniam, Vincent, Gardner, Chan, Dhamko, Jothy: "CD44 regulates cell migration in human colon cancer cells via Lyn kinase and AKT phosphorylation." in: Experimental and molecular pathology, Vol. 83, Issue 2, pp. 207-15, (2007) (PubMed).

Subramaniam, Gardner, Jothy: "Soluble CD44 secretion contributes to the acquisition of aggressive tumor phenotype in human colon cancer cells." in: Experimental and molecular pathology, Vol. 83, Issue 3, pp. 341-6, (2007) (PubMed).

Target Details for CD44

Target: CD44

Alternative Name: CD44 / PGP-1 / HUTCH-I (CD44 Products)

Synonyms: CDW44 antibody, CSPG8 antibody, ECMR-III antibody, HCELL antibody, HUTCH-I antibody, IN antibody, LHR antibody, MC56 antibody, MDU2 antibody, MDU3 antibody, MIC4 antibody, Pgp1 antibody, AU023126 antibody, AW121933 antibody, AW146109 antibody, HERMES antibody, Ly-24 antibody, Pgp-1 antibody, CD44A antibody, METAA antibody, RHAMM antibody, XCD44 antibody, cd44 antibody, cdw44 antibody, cspg8 antibody, ecmr-iii antibody, hcell antibody, lhr antibody, mc56 antibody, mdu2 antibody, mdu3 antibody, mic4 antibody, mutch-i antibody, pgp1 antibody, CD44 molecule (Indian blood group) antibody, syndecan 4 antibody, CD44 antigen antibody, CD44 molecule (Indian blood group) S homeolog antibody, CD44 antibody, SDC4 antibody, Cd44 antibody, cd44.S antibody

Gene ID: 960

Pathways: Glycosaminoglycan Metabolic Process, Autophagy, Negative Regulation of intrinsic apoptotic Signaling