IGF2R antibody

Catalog No. ABIN535479

Product Details anti-IGF2R Antibody

Target: IGF2R (Insulin-Like Growth Factor 2 Receptor (IGF2R))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IGF2R antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Purpose: Mouse monoclonal antibody raised against recombinant IGF2R.

Specificity: This antibody recognizes an epitope between domains 2 and 5 of CD222 (IGF2 receptor), a ubiquitously expressed 250 KDa multifunctional type I transmembrane protein.The majority of CD222 is found in the late endosomal/prelysosomal compartment, 5-10 % inthe plasma membrane and the truncated (220 KDa) form of CD222 is present in human and bovine serum.

Cross-Reactivity: Human

Immunogen: Recombinant protein corresponding to human IGF2R.

Clone: MEM-238

Isotype: IgG1

Application Details

Application Notes: The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: In PBS, pH 7.4 (0.09 % sodium azide)

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 4°C. Do not freeze.
Avoid repeated freezing and thawing.

References for anti-IGF2R antibody (ABIN535479)

Wood, Hulett: "Cell surface-expressed cation-independent mannose 6-phosphate receptor (CD222) binds enzymatically active heparanase independently of mannose 6-phosphate to promote extracellular matrix degradation." in: The Journal of biological chemistry, Vol. 283, Issue 7, pp. 4165-76, (2008) (PubMed).

Leksa, Godar, Schiller, Fuertbauer, Muhammad, Slezakova, Horejsi, Steinlein, Weidle, Binder, Stockinger: "TGF-beta-induced apoptosis in endothelial cells mediated by M6P/IGFII-R and mini-plasminogen." in: Journal of cell science, Vol. 118, Issue Pt 19, pp. 4577-86, (2005) (PubMed).

Gasanov, Koina, Beagley, Aitken, Hansbro: "Identification of the insulin-like growth factor II receptor as a novel receptor for binding and invasion by Listeria monocytogenes." in: Infection and immunity, Vol. 74, Issue 1, pp. 566-77, (2005) (PubMed).

Target Details for IGF2R

Target: IGF2R (Insulin-Like Growth Factor 2 Receptor (IGF2R))

Alternative Name: CD222 / IGF2R (IGF2R Products)

Synonyms: CD222 antibody, CIMPR antibody, M6P-R antibody, MPR1 antibody, MPRI antibody, AI661837 antibody, CI-MPR antibody, M6P/IGF2R antibody, Mpr300 antibody, mpri antibody, cd222 antibody, cimpr antibody, m6p-r antibody, insulin like growth factor 2 receptor antibody, insulin-like growth factor 2 receptor antibody, IGF2R antibody, Igf2r antibody, igf2r antibody

Gene ID: 3482