LAT antibody

Catalog No. ABIN535482

Product Details anti-LAT Antibody

Target: LAT (Linker For Activation of T Cells (LAT))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This LAT antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Flow Cytometry (FACS)

Purpose: Mouse monoclonal antibody raised against partial recombinant LAT.

Specificity: This antibody reacts with Linker for activation of T cells (LAT), a 36-38 KDa transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells and platelets.

Cross-Reactivity: Human

Immunogen: Recombinant protein corresponding to cytoplasmic region of human LAT.

Clone: LAT-01

Isotype: IgG1

Application Details

Application Notes: The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In PBS, pH 7.4 (0.09 % sodium azide)

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 4°C. Do not freeze.
Aliquot to avoid repeated freezing and thawing.

References for anti-LAT antibody (ABIN535482)

Yamasaki, Ishikawa, Sakuma, Kanagawa, Cheng, Malissen, Saito: "LAT and NTAL mediate immunoglobulin E-induced sustained extracellular signal-regulated kinase activation critical for mast cell survival." in: Molecular and cellular biology, Vol. 27, Issue 12, pp. 4406-15, (2007) (PubMed).

Tedoldi, Paterson, Hansmann, Natkunam, Rüdiger, Angelisova, Du, Roberton, Roncador, Sanchez, Pozzobon, Masir, Barry, Pileri, Mason, Marafioti, Horejsí: "Transmembrane adaptor molecules: a new category of lymphoid-cell markers." in: Blood, Vol. 107, Issue 1, pp. 213-21, (2005) (PubMed).

Simeoni, Smida, Posevitz, Schraven, Lindquist: "Right time, right place: the organization of membrane proximal signaling." in: Seminars in immunology, Vol. 17, Issue 1, pp. 35-49, (2004) (PubMed).

Target Details for LAT

Target: LAT (Linker For Activation of T Cells (LAT))

Alternative Name: LAT (LAT Products)

Synonyms: LAT antibody, lat antibody, LAT1 antibody, pp36 antibody, linker for activation of T-cells antibody, linker for activation of T cells antibody, LAT antibody, lat antibody, Lat antibody

Gene ID: 27040

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway