CD45 antibody

Catalog No. ABIN535487

Product Details anti-CD45 Antibody

Target: CD45 (PTPRC) (Protein tyrosine Phosphatase, Receptor Type, C (PTPRC))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD45 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Purpose: Mouse monoclonal antibody raised against native PTPRC.

Specificity: This antibody reacts with a protein determinant of CD45RB, a 180-240 KDa singlechain type I membrane glycoprotein, variant of CD45 (CD45RB isoform). CD45RB isexpressed on a subset of T lymphocytes, B lymphocytes, monocytes, macrophages, granulocytes and dendritic cells.The MEM-143 is therefore not neuraminidase sensitive. The reactivity of This antibody can be blocked by a peptide including amino acids 79-88.

Cross-Reactivity: Human

Immunogen: Native purified PTPRC from human peripheral blood lymphocytes.

Clone: MEM-143

Isotype: IgG1

Application Details

Application Notes: The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In PBS, pH 7.4 (0.09 % sodium azide)

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 4°C. Do not freeze.
Aliquot to avoid repeated freezing and thawing.

References for anti-CD45 antibody (ABIN535487)

Desharnais, Dupéré-Minier, Hamelin, Devine, Bernier: "Involvement of CD45 in DNA fragmentation in apoptosis induced by mitochondrial perturbing agents." in: Apoptosis : an international journal on programmed cell death, Vol. 13, Issue 2, pp. 197-212, (2008) (PubMed).

Bijian, Zhang, Shen: "Collagen-mediated survival signaling is modulated by CD45 in Jurkat T cells." in: Molecular immunology, Vol. 44, Issue 15, pp. 3682-90, (2007) (PubMed).

Dawes, Petrova, Liu, Wraith, Beverley, Tchilian: "Combinations of CD45 isoforms are crucial for immune function and disease." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 176, Issue 6, pp. 3417-25, (2006) (PubMed).

Target Details for CD45

Target: CD45 (PTPRC) (Protein tyrosine Phosphatase, Receptor Type, C (PTPRC))

Alternative Name: PTPRC (PTPRC Products)

Synonyms: PTPRC antibody, si:dkeyp-47c5.1 antibody, B220 antibody, CD45 antibody, CD45R antibody, GP180 antibody, L-CA antibody, LCA antibody, LY5 antibody, T200 antibody, Cd45 antibody, Ly-5 antibody, Lyt-4 antibody, loc antibody, Lca antibody, RT7 antibody, cd45 antibody, protein tyrosine phosphatase, receptor type C antibody, protein tyrosine phosphatase, receptor type, C antibody, receptor-type tyrosine-protein phosphatase C antibody, PTPRC antibody, ptprc antibody, LOC100074271 antibody, Ptprc antibody

Gene ID: 5788

Pathways: TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, CXCR4-mediated Signaling Events, BCR Signaling