CD46 antibody (PE)

Catalog No. ABIN536016

Product Details anti-CD46 Antibody (PE)

Target: CD46

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD46 antibody is conjugated to PE

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP)

Purpose: Mouse monoclonal antibody raised against native CD46.

Specificity: This antibody recognizes an epitope on SCR4 (the membrane-proximal SCR) domain of CD46 (Membrane cofactor protein). CD46 is 56-66 KDa dimeric transmembrane protein expressed on T and B lymphocytes, platelets, monocytes, granulocytes, endothelial cells, epithelial cells and fibroblast, it is negative on erythrocytes.

Cross-Reactivity: Cow, Human

Immunogen: Native purified CD46 from human T cell line HPB-ALL.

Clone: MEM-258

Isotype: IgG1

Application Details

Application Notes: Flow Cytometry (20 µL in human blood cells 100 µL in whole blood or 10⁶ cells in a suspension)
The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In PBS (0.2 % BSA, 0.09 % sodium azide)

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.

References for anti-CD46 antibody (PE) (ABIN536016)

Oliaro, Pasam, Waterhouse, Browne, Ludford-Menting, Trapani, Russell: "Ligation of the cell surface receptor, CD46, alters T cell polarity and response to antigen presentation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 49, pp. 18685-90, (2006) (PubMed).

Liszewski, Kemper, Price, Atkinson: "Emerging roles and new functions of CD46." in: Springer seminars in immunopathology, Vol. 27, Issue 3, pp. 345-58, (2005) (PubMed).

Gaggar, Shayakhmetov, Lieber: "CD46 is a cellular receptor for group B adenoviruses." in: Nature medicine, Vol. 9, Issue 11, pp. 1408-12, (2003) (PubMed).

Target Details for CD46

Target: CD46

Alternative Name: CD46 / MCP (CD46 Products)

Synonyms: AHUS2 antibody, MCP antibody, MIC10 antibody, TLX antibody, TRA2.10 antibody, Mcp antibody, CD46 antibody, CD46 molecule antibody, CD46 antigen, complement regulatory protein antibody, CD46 molecule, complement regulatory protein antibody, membrane cofactor protein-like antibody, CD46 antibody, Cd46 antibody, LOC100341359 antibody, LOC103789310 antibody

Gene ID: 4179

Pathways: Regulation of Actin Filament Polymerization