TNFRSF8 antibody (PE)

Catalog No. ABIN536665

Product Details anti-TNFRSF8 Antibody (PE)

Target: TNFRSF8 (Tumor Necrosis Factor Receptor Superfamily, Member 8 (TNFRSF8))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TNFRSF8 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Purpose: Mouse monoclonal antibody raised against TNFRSF8.

Specificity: This antibody recognizes extracellular part of CD30 (Ki-1 antigen), a 105 KDa single chain glycoprotein expressed on Hodgkin's and Reed-Sternberg cells.

Cross-Reactivity: Human

Immunogen: Expression vector containing CD30 cDNA (booster suspension of THP-1 cell line).

Clone: MEM-268

Isotype: IgG

Application Details

Application Notes: Flow Cytometry (20 µL in human blood cells 100 µL in whole blood or 10⁶ cells in a suspension)
The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In PBS (0.2 % BSA, 0.09 % sodium azide)

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.

References for anti-TNFRSF8 antibody (PE) (ABIN536665)

Kusanovic, Romero, Hassan, Gotsch, Edwin, Chaiworapongsa, Erez, Mittal, Mazaki-Tovi, Soto, Than, Friel, Yoon, Espinoza: "Maternal serum soluble CD30 is increased in normal pregnancy, but decreased in preeclampsia and small for gestational age pregnancies." in: The journal of maternal-fetal & neonatal medicine, Vol. 20, Issue 12, pp. 867-78, (2008) (PubMed).

Wright, Rumble, Duckett: "CD30 activates both the canonical and alternative NF-kappaB pathways in anaplastic large cell lymphoma cells." in: The Journal of biological chemistry, Vol. 282, Issue 14, pp. 10252-62, (2007) (PubMed).

Zeiser, Nguyen, Hou, Beilhack, Zambricki, Buess, Contag, Negrin: "Early CD30 signaling is critical for adoptively transferred CD4+CD25+ regulatory T cells in prevention of acute graft-versus-host disease." in: Blood, Vol. 109, Issue 5, pp. 2225-33, (2007) (PubMed).

Target Details for TNFRSF8

Target: TNFRSF8 (Tumor Necrosis Factor Receptor Superfamily, Member 8 (TNFRSF8))

Alternative Name: CD30 (TNFRSF8 Products)

Synonyms: CD30 antibody, D1S166E antibody, Ki-1 antibody, Cd30 antibody, Ki antibody, TNFRSF8 antibody, TNF receptor superfamily member 8 antibody, tumor necrosis factor receptor superfamily, member 8 antibody, TNFRSF8 antibody, Tnfrsf8 antibody

Gene ID: 943