Separase antibody (pSer1126)

Catalog No. ABIN537755

Product Details anti-Separase Antibody

Target: Separase (ESPL1) (Extra Spindle Poles Like 1 (ESPL1))

Binding Specificity: pSer1126

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Separase antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Dot Blot (DB)

Purpose: Rabbit polyclonal antibody raised against synthetic phosphopeptide of ESPL1.

Cross-Reactivity: Human

Immunogen: Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S1126 of human ESPL1.

Application Details

Application Notes: Dot Blot (1:500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In PBS (0.09 % sodium azide)

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.

References for anti-Separase antibody (ABIN537755)

Chestukhin, Pfeffer, Milligan, DeCaprio, Pellman: "Processing, localization, and requirement of human separase for normal anaphase progression." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 8, pp. 4574-9, (2003) (PubMed).

Waizenegger, Giménez-Abián, Wernic, Peters: "Regulation of human separase by securin binding and autocleavage." in: Current biology : CB, Vol. 12, Issue 16, pp. 1368-78, (2002) (PubMed).

Chen, Kamradt, Mulcahy, Byun, Xu, McKay, Cryns: "Caspase proteolysis of the cohesin component RAD21 promotes apoptosis." in: The Journal of biological chemistry, Vol. 277, Issue 19, pp. 16775-81, (2002) (PubMed).

Target Details for Separase

Target: Separase (ESPL1) (Extra Spindle Poles Like 1 (ESPL1))

Alternative Name: Separin / ESPL1 (ESPL1 Products)

Synonyms: ESP1 antibody, SEPA antibody, mp:zf637-3-001691 antibody, AL024103 antibody, AU045071 antibody, Cerp antibody, PRCE antibody, SSE antibody, extra spindle pole bodies like 1, separase antibody, extra spindle poles like 1 antibody, extra spindle pole bodies 1, separase antibody, ESPL1 antibody, espl1 antibody, Espl1 antibody

Gene ID: 9700