ATR antibody (Ser428)

Catalog No. ABIN540506

Product Details anti-ATR Antibody

Target: ATR (ATR serine/threonine kinase (ATR))

Binding Specificity: Ser428

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATR antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Rabbit polyclonal antibody raised against synthetic peptide of ATR.

Sequence: GISPK

Specificity: ATR (Ab-428) Antiobdy detects endogenous levels of total ATR protein.

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Synthetic Peptide.

Immunogen: A synthetic peptide (conjugated with KLH) corresponding to residues surrounding S428 of human ATR.

Application Details

Application Notes: Immunohistochemistry (1:50-1:100)
The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: In PBS (without Mg²⁺ and Ca²⁺), 150 mM NaCl, pH 7.4 (50 % glycerol, 0.02 % sodium azide)

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C.
Aliquot to avoid repeated freezing and thawing.

References for anti-ATR antibody (ABIN540506)

Shechter, Costanzo, Gautier: "Regulation of DNA replication by ATR: signaling in response to DNA intermediates." in: DNA repair, Vol. 3, Issue 8-9, pp. 901-8, (2004) (PubMed).

Zhou, Lu, Wulf, Lu: "Phosphorylation-dependent prolyl isomerization: a novel signaling regulatory mechanism." in: Cellular and molecular life sciences : CMLS, Vol. 56, Issue 9-10, pp. 788-806, (2001) (PubMed).

Kastan, Lim: "The many substrates and functions of ATM." in: Nature reviews. Molecular cell biology, Vol. 1, Issue 3, pp. 179-86, (2001) (PubMed).

Target Details for ATR

Target: ATR (ATR serine/threonine kinase (ATR))

Alternative Name: ATR (ATR Products)

Synonyms: FCTCS antibody, FRP1 antibody, MEC1 antibody, SCKL antibody, SCKL1 antibody, ATR serine/threonine kinase antibody, ataxia telangiectasia and Rad3 related antibody, ATR antibody, Atr antibody

Gene ID: 545

Pathways: Positive Regulation of Response to DNA Damage Stimulus