Nibrin antibody

Catalog No. ABIN540667

Product Details anti-Nibrin Antibody

Target: Nibrin (NBN)

Reactivity: Please inquire

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Nibrin antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunoprecipitation (IP)

Purpose: Rabbit polyclonal antibody raised against partial recombinant NBN.

Specificity: This antibody is specific to human NBS1.

Immunogen: Recombinant protein corresponding to amino acids 1-705 of human NBN.

Application Details

Application Notes: Immunocytochemistry (1:50-1:200)
Immunofluorescence (1:200)
Immunoprecipitation (3 μg/mL)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In antiserum (0.09 % sodium azide)

Storage: 4 °C

Storage Comment: Store at 4°C. Do not freeze.

References for anti-Nibrin antibody (ABIN540667)

Compton, Choi, Cesare, Ozgür, Griffith: "Xrcc3 and Nbs1 are required for the production of extrachromosomal telomeric circles in human alternative lengthening of telomere cells." in: Cancer research, Vol. 67, Issue 4, pp. 1513-9, (2007) (PubMed).

Gueven, Becherel, Birrell, Chen, DelSal, Carney, Grattan-Smith, Lavin: "Defective p53 response and apoptosis associated with an ataxia-telangiectasia-like phenotype." in: Cancer research, Vol. 66, Issue 6, pp. 2907-12, (2006) (PubMed).

McCabe, Turner, Lord, Kluzek, Bialkowska, Swift, Giavara, OConnor, Tutt, Zdzienicka, Smith, Ashworth: "Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition." in: Cancer research, Vol. 66, Issue 16, pp. 8109-15, (2006) (PubMed).

Mirzoeva, Kawaguchi, Pieper: "The Mre11/Rad50/Nbs1 complex interacts with the mismatch repair system and contributes to temozolomide-induced G2 arrest and cytotoxicity." in: Molecular cancer therapeutics, Vol. 5, Issue 11, pp. 2757-66, (2006) (PubMed).

Lukas, Falck, Bartkova, Bartek, Lukas: "Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage." in: Nature cell biology, Vol. 5, Issue 3, pp. 255-60, (2003) (PubMed).

Target Details for Nibrin

Target: Nibrin (NBN)

Alternative Name: Nibrin (NBN Products)

Synonyms: NBN antibody, AT-V1 antibody, AT-V2 antibody, ATV antibody, NBS antibody, NBS1 antibody, P95 antibody, Nbs1 antibody, im:6911679 antibody, zgc:194152 antibody, nibrin antibody, NBN antibody, nbn antibody, Nbn antibody

Pathways: DNA Damage Repair, Production of Molecular Mediator of Immune Response