FANCD2 antibody (N-Term)

Catalog No. ABIN540721

Product Details anti-FANCD2 Antibody

Target: FANCD2 (Fanconi Anemia, Complementation Group D2 (FANCD2))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FANCD2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)

Purpose: Rabbit polyclonal antibody raised against partial recombinant FANCD2.

Specificity: This antibody is specific to FANCD2.

Cross-Reactivity: Human, Mouse

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: Recombinant protein corresponding to N-terminus of human FANCD2.

Application Details

Application Notes: Immunofluorescence (1:200-1:500)
Western Blot (1:10000-1:20000)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (2.5-5 μg/mL)
The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In Tris-glycine, 150 mM NaCl (0.05 % sodium azide)

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C or -80°C.
Aliquot to avoid repeated freezing and thawing.

References for anti-FANCD2 antibody (ABIN540721)

Bekker-Jensen, Lukas, Kitagawa, Melander, Kastan, Bartek, Lukas: "Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks." in: The Journal of cell biology, Vol. 173, Issue 2, pp. 195-206, (2006) (PubMed).

Tremblay, Pintor Dos Reis, Bradley, Galloni, Perez-Ordonez, Freeman, Brown, Gilbert, Gullane, Irish, Kamel-Reid: "Young patients with oral squamous cell carcinoma: study of the involvement of GSTP1 and deregulation of the Fanconi anemia genes." in: Archives of otolaryngology--head & neck surgery, Vol. 132, Issue 9, pp. 958-66, (2006) (PubMed).

Mukhopadhyay, Leung, Hicks, Hastings, Youssoufian, Plon: "Defective mitochondrial peroxiredoxin-3 results in sensitivity to oxidative stress in Fanconi anemia." in: The Journal of cell biology, Vol. 175, Issue 2, pp. 225-35, (2006) (PubMed).

Stiff, Reis, Alderton, Woodbine, ODriscoll, Jeggo: "Nbs1 is required for ATR-dependent phosphorylation events." in: The EMBO journal, Vol. 24, Issue 1, pp. 199-208, (2005) (PubMed).

Rothfuss, Grompe: "Repair kinetics of genomic interstrand DNA cross-links: evidence for DNA double-strand break-dependent activation of the Fanconi anemia/BRCA pathway." in: Molecular and cellular biology, Vol. 24, Issue 1, pp. 123-34, (2003) (PubMed).

Target Details for FANCD2

Target: FANCD2 (Fanconi Anemia, Complementation Group D2 (FANCD2))

Alternative Name: FANCD2 (FANCD2 Products)

Synonyms: FANCD2 antibody, CG17269 antibody, CG31192 antibody, CG31194 antibody, Dmel\\CG17269 antibody, dmFANCD2 antibody, xfancd2 antibody, FA-D2 antibody, FA4 antibody, FACD antibody, FAD antibody, FAD2 antibody, FANCD antibody, 2410150O07Rik antibody, AU015151 antibody, BB137857 antibody, Fanconi anemia complementation group D2 antibody, CG17269 gene product from transcript CG17269-RA antibody, Fanconi anemia group D2 protein antibody, Fanconi anemia, complementation group D2 antibody, Fanconi anemia complementation group D2 L homeolog antibody, FANCD2 antibody, Fancd2 antibody, LOC100455970 antibody, fancd2 antibody, fancd2.L antibody

Gene ID: 2177

Pathways: DNA Damage Repair