PKD2 antibody (C-Term)

Catalog No. ABIN543268

Product Details anti-PKD2 Antibody

Target: PKD2 (Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PKD2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Rabbit polyclonal antibody raised against synthetic peptide of PKD2.

Cross-Reactivity: Human

Immunogen: A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human PKD2.

Application Details

Application Notes: Western Blot (1:1000)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In PBS (0.09 % sodium azide)

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.

References for anti-PKD2 antibody (ABIN543268)

Gargalionis, Korkolopoulou, Farmaki, Piperi, Dalagiorgou, Adamopoulos, Levidou, Saetta, Fragkou, Tsioli, Kiaris, Zizi-Serbetzoglou, Karavokyros, Papavassiliou, Tsavaris, Patsouris, Basdra et al.: "Polycystin-1 and polycystin-2 are involved in the acquisition of aggressive phenotypes in colorectal cancer. ..." in: International journal of cancer. Journal international du cancer, Vol. 136, Issue 7, pp. 1515-27, (2015) (PubMed).

Varela, Piperi, Sigala, Agrogiannis, Davos, Andri, Manopoulos, Tsangaris, Basdra, Papavassiliou: "Elevated expression of mechanosensory polycystins in human carotid atherosclerotic plaques: association with p53 activation and disease severity." in: Scientific reports, Vol. 5, pp. 13461, (2015) (PubMed).

Stayner, Zhou: "Polycystin channels and kidney disease." in: Trends in pharmacological sciences, Vol. 22, Issue 11, pp. 543-6, (2001) (PubMed).

Watnick, He, Wang, Liang, Parfrey, Hefferton, St George-Hyslop, Germino, Pei: "Mutations of PKD1 in ADPKD2 cysts suggest a pathogenic effect of trans-heterozygous mutations." in: Nature genetics, Vol. 25, Issue 2, pp. 143-4, (2000) (PubMed).

Lehtonen, Ora, Olkkonen, Geng, Zerial, Somlo, Lehtonen: "In vivo interaction of the adapter protein CD2-associated protein with the type 2 polycystic kidney disease protein, polycystin-2." in: The Journal of biological chemistry, Vol. 275, Issue 42, pp. 32888-93, (2000) (PubMed).

Target Details for PKD2

Target: PKD2 (Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2))

Alternative Name: PKD2 (PKD2 Products)

Synonyms: APKD2 antibody, PC2 antibody, PKD4 antibody, Pc-2 antibody, TRPP2 antibody, C030034P18Rik antibody, RGD1559992 antibody, pkd2 antibody, trpp2 antibody, Cup antibody, PKD2L1 antibody, polycystin 2, transient receptor potential cation channel antibody, polycystic kidney disease 2 antibody, Polycystin-2 antibody, polycystin 2, transient receptor potential cation channel L homeolog antibody, PKD2 antibody, Pkd2 antibody, pkd-2 antibody, pkd2.L antibody, pkd2 antibody

Gene ID: 5311

Pathways: cAMP Metabolic Process, Maintenance of Protein Location, Negative Regulation of Transporter Activity