MLL/KMT2A antibody (AA 312-343)

Catalog No. ABIN543317

Product Details anti-MLL/KMT2A Antibody

Target: MLL/KMT2A (MLL) (Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL))

Binding Specificity: AA 312-343

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MLL/KMT2A antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Rabbit polyclonal antibody raised against synthetic peptide of MLL.

Cross-Reactivity: Human

Immunogen: A synthetic peptide (conjugated with KLH) corresponding to amino acids 312-343 at C-terminus of human MLL.

Application Details

Application Notes: Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In PBS (0.09 % sodium azide)

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.

References for anti-MLL/KMT2A antibody (ABIN543317)

Pegram, Megonigal, Lange, Nowell, Rowley, Rappaport, Felix: "t(3;11) translocation in treatment-related acute myeloid leukemia fuses MLL with the GMPS (GUANOSINE 5' MONOPHOSPHATE SYNTHETASE) gene." in: Blood, Vol. 96, Issue 13, pp. 4360-2, (2000) (PubMed).

Sano, Hayakawa, Piao, Kosaka, Nakamura: "Novel SH3 protein encoded by the AF3p21 gene is fused to the mixed lineage leukemia protein in a therapy-related leukemia with t(3;11) (p21;q23)." in: Blood, Vol. 95, Issue 3, pp. 1066-8, (2000) (PubMed).

Megonigal, Cheung, Rappaport, Nowell, Wilson, Jones, Addya, Leonard, Kushner, Williams, Lange, Felix: "Detection of leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitors." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 6, pp. 2814-9, (2000) (PubMed).

Target Details for MLL/KMT2A

Target: MLL/KMT2A (MLL) (Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL))

Alternative Name: MLL / HRX (MLL Products)

Gene ID: 4297

Pathways: Warburg Effect