LGR5 antibody (AA 451-480)

Catalog No. ABIN543553

Product Details anti-LGR5 Antibody

Target: LGR5 (Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5))

Binding Specificity: AA 451-480

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LGR5 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Rabbit polyclonal antibody raised against synthetic peptide of LGR5.

Cross-Reactivity: Human

Immunogen: A synthetic peptide (conjugated with KLH) corresponding to amino acids 451-480 at internal region of human LGR5.

Application Details

Application Notes: Western Blot (1:1000)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In PBS (0.09 % sodium azide)

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.

References for anti-LGR5 antibody (ABIN543553)

Barker, van Es, Kuipers, Kujala, van den Born, Cozijnsen, Haegebarth, Korving, Begthel, Peters, Clevers: "Identification of stem cells in small intestine and colon by marker gene Lgr5." in: Nature, Vol. 449, Issue 7165, pp. 1003-7, (2007) (PubMed).

McClanahan, Koseoglu, Smith, Grein, Gustafson, Black, Kirschmeier, Samatar: "Identification of overexpression of orphan G protein-coupled receptor GPR49 in human colon and ovarian primary tumors." in: Cancer biology & therapy, Vol. 5, Issue 4, pp. 419-26, (2006) (PubMed).

Yamamoto, Sakamoto, Fujii, Tsuiji, Kenetaka, Asaka, Hirohashi: "Overexpression of orphan G-protein-coupled receptor, Gpr49, in human hepatocellular carcinomas with beta-catenin mutations." in: Hepatology (Baltimore, Md.), Vol. 37, Issue 3, pp. 528-33, (2003) (PubMed).

Target Details for LGR5

Target: LGR5 (Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5))

Alternative Name: LGR5 / GPR49 (LGR5 Products)

Synonyms: lgr5-a antibody, lgr5a antibody, FEX antibody, Gpr49 antibody, GPR49 antibody, GPR67 antibody, GRP49 antibody, HG38 antibody, leucine-rich repeat containing G protein-coupled receptor 5 L homeolog antibody, leucine rich repeat containing G protein coupled receptor 5 antibody, leucine rich repeat containing G protein-coupled receptor 5 antibody, lgr5.L antibody, Lgr5 antibody, LGR5 antibody

Gene ID: 8549

Pathways: WNT Signaling