Insulin Receptor antibody (pTyr1185)

Catalog No. ABIN548700

Product Details anti-Insulin Receptor Antibody

Target: Insulin Receptor (INSR)

Binding Specificity: pTyr1185

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Insulin Receptor antibody is un-conjugated

Application: ELISA, Dot Blot (DB)

Purpose: Rabbit polyclonal antibody raised against synthetic phosphopeptide of INSR.

Cross-Reactivity: Human

Immunogen: Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding Y1185 of human INSR.

Application Details

Application Notes: ELISA (1:1000)
Dot Blot (1:500)
The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In PBS (0.09 % sodium azide)

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.

References for anti-Insulin Receptor antibody (ABIN548700)

McGettrick, Feener, Kahn: "Human insulin receptor substrate-1 (IRS-1) polymorphism G972R causes IRS-1 to associate with the insulin receptor and inhibit receptor autophosphorylation." in: The Journal of biological chemistry, Vol. 280, Issue 8, pp. 6441-6, (2005) (PubMed).

Nakamaru, Matsumoto, Taguchi, Suefuji, Murata, Igata, Kawashima, Kondo, Motoshima, Tsuruzoe, Miyamura, Toyonaga, Araki: "AICAR, an activator of AMP-activated protein kinase, down-regulates the insulin receptor expression in HepG2 cells." in: Biochemical and biophysical research communications, Vol. 328, Issue 2, pp. 449-54, (2005) (PubMed).

Díaz, Cárdenas, Ariza, Larrea, Halhali: "Placental insulin and insulin-like growth factor I receptors in normal and preeclamptic pregnancies." in: Clinical biochemistry, Vol. 38, Issue 3, pp. 243-7, (2005) (PubMed).

Target Details for Insulin Receptor

Target: Insulin Receptor (INSR)

Alternative Name: CD220 / INSR (INSR Products)

Synonyms: CD220 antibody, HHF5 antibody, 4932439J01Rik antibody, D630014A15Rik antibody, IR antibody, IR-A antibody, IR-B antibody, 18402 antibody, CG18402 antibody, DIHR antibody, DILR antibody, DIR antibody, DIRH antibody, DIRbeta antibody, DInR antibody, DInr antibody, Dir-a antibody, Dir-b antibody, Dmel\\CG18402 antibody, INR antibody, INS antibody, Inr antibody, Inr-alpha antibody, Inr-beta antibody, InsR antibody, dINR antibody, dIR antibody, dIRH antibody, dInR antibody, dInr antibody, dInsR antibody, dinr antibody, dir antibody, er10 antibody, inr antibody, insulin/insulin-like growth factor receptor antibody, l(3)05545 antibody, l(3)93Dj antibody, l(3)er10 antibody, lnR antibody, ir-A antibody, CTK-1 antibody, ir antibody, INSR antibody, NV14476 antibody, cd220 antibody, hhf5 antibody, insulin receptor antibody, Insulin-like receptor antibody, insulin receptor L homeolog antibody, INSR antibody, Insr antibody, InR antibody, LOC100122567 antibody, LOC100451802 antibody, insr.L antibody

Gene ID: 3643

Pathways: NF-kappaB Signaling, RTK Signaling, AMPK Signaling, Carbohydrate Homeostasis, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Growth Factor Binding, Negative Regulation of Transporter Activity