c-MET antibody (pTyr1349, pTyr1356)

Catalog No. ABIN550491

Product Details anti-c-MET Antibody

Target: c-MET (MET) (Met Proto-Oncogene (MET))

Binding Specificity: pTyr1349, pTyr1356

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This c-MET antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purpose: Rabbit polyclonal antibody raised against synthetic phosphopeptide of MET.

Specificity: This antibody is specific to human c-Met protein phosphorylated at Y1349 and Y1356.

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Antibody Reactive Against Synthetic Peptide.

Immunogen: Synthetic phosphopeptide corresponding to residues surrounding Y1349/Y1356 of human MET.

Application Details

Application Notes: ELISA (1:450000)
Western Blot (1:500-1:2000)
The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 20 mM KH₂PO₄, 150 mM NaCl, pH 7.2 (0.01 % sodium azide)

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.

References for anti-c-MET antibody (ABIN550491)

Pavone, Cattaneo, Rea, De Pasquale, Spina, Sauchelli, Mastellone, Ammendola: "Intracellular signaling cascades triggered by the NK1 fragment of hepatocyte growth factor in human prostate epithelial cell line PNT1A." in: Cellular signalling, Vol. 23, Issue 12, pp. 1961-71, (2011) (PubMed).

Birchmeier, Birchmeier, Gherardi, Vande Woude: "Met, metastasis, motility and more." in: Nature reviews. Molecular cell biology, Vol. 4, Issue 12, pp. 915-25, (2003) (PubMed).

Fan, Ma, Gao, Yuan, Meng, Goldberg, Rosen: "The multisubstrate adapter Gab1 regulates hepatocyte growth factor (scatter factor)-c-Met signaling for cell survival and DNA repair." in: Molecular and cellular biology, Vol. 21, Issue 15, pp. 4968-84, (2001) (PubMed).

Longati, Comoglio, Bardelli: "Receptor tyrosine kinases as therapeutic targets: the model of the MET oncogene." in: Current drug targets, Vol. 2, Issue 1, pp. 41-55, (2001) (PubMed).

Target Details for c-MET

Target: c-MET (MET) (Met Proto-Oncogene (MET))

Alternative Name: HGF receptor (MET Products)

Synonyms: AUTS9 antibody, HGFR antibody, RCCP2 antibody, c-Met antibody, AI838057 antibody, HGF antibody, Par4 antibody, Hgfr antibody, c-met antibody, MET antibody, C-MET antibody, met antibody, met-A antibody, MET proto-oncogene, receptor tyrosine kinase antibody, met proto-oncogene antibody, MET proto-oncogene, receptor tyrosine kinase L homeolog antibody, MET antibody, Met antibody, met.L antibody

Gene ID: 4233

Pathways: RTK Signaling, Carbohydrate Homeostasis, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor