IBTK antibody (C-Term)

Catalog No. ABIN5514895

Product Details anti-IBTK Antibody

Target: IBTK (Inhibitor of Bruton Agammaglobulinemia Tyrosine Kinase (IBTK))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IBTK antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: GDIFLKEEIN MEQNHSETMF KKAKTKAKKK PRKRSDSSGG YNLSDIIQSP

Characteristics: This is a rabbit polyclonal antibody against IBTK. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human IBTK

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for IBTK

Target: IBTK (Inhibitor of Bruton Agammaglobulinemia Tyrosine Kinase (IBTK))

Alternative Name: IBTK (IBTK Products)

Synonyms: IBTK antibody, fi40c08 antibody, wu:fi40c08 antibody, DKFZp468J085 antibody, BTBD26 antibody, BTKI antibody, RP1-93K22.1 antibody, 5430411K16Rik antibody, AA409502 antibody, mKIAA1417 antibody, inhibitor of Bruton tyrosine kinase antibody, inhibitor of Bruton agammaglobulinemia tyrosine kinase antibody, inhibitor of Bruton tyrosine kinase L homeolog antibody, IBTK antibody, ibtk antibody, Ibtk antibody, ibtk.L antibody

Background: Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Alias Symbols: IBTK, BTKI, KIAA1417,

Protein Interaction Partner: IGSF8, CD81, LAMTOR3, ITK, BTK, AKT1, PRKD1, PRKCG, PRKCE, PRKCD, PRKCB, PRKCA, PLCG1, CUL3, PPP1CA, UBC, RGS2,

Protein Size: 1353

Gene ID: 25998

NCBI Accession: NP_056340

UniProt: Q9P2D0