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APEX2 antibody (C-Term)

APEX2 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN5515372
  • Target See all APEX2 Antibodies
    APEX2 (APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2))
    Binding Specificity
    • 15
    • 7
    • 6
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 20
    • 16
    • 15
    Human
    Host
    • 34
    • 2
    Rabbit
    Clonality
    • 36
    Polyclonal
    Conjugate
    • 12
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This APEX2 antibody is un-conjugated
    Application
    • 34
    • 17
    • 15
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    LMTPKTPEEK AVAKVVKGQA KTSEAKDEKE LRTSFWKSVL AGPLRTPLCG
    Predicted Reactivity
    Cow: 85%, Horse: 93%, Human: 100%, Rat: 77%
    Purification
    Affinity purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the C terminal region of human APEX2
    Top Product
    Discover our top product APEX2 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    APEX2 (APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2))
    Alternative Name
    APEX2 (APEX2 Products)
    Synonyms
    APE2 antibody, APEXL2 antibody, XTH2 antibody, ape2 antibody, apexl2 antibody, xth2 antibody, zgc:55889 antibody, C430040P13Rik antibody, apurinic/apyrimidinic endodeoxyribonuclease 2 antibody, APEX nuclease (apurinic/apyrimidinic endonuclease) 2 antibody, apurinic/apyrimidinic endodeoxyribonuclease 2 L homeolog antibody, apurinic/apyrimidinic endonuclease 2 antibody, APEX2 antibody, apex2 antibody, apex2.L antibody, Apex2 antibody
    Background
    Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

    Alias Symbols: APE2, XTH2, ZGRF2, APEXL2

    Protein Interaction Partner: UBC, PDE12, APP, NEDD4L, CCDC85B, NINL, HOOK2, PGR, CALCOCO2, TRIM37, EFEMP2, TRAF2, PCNA,

    Protein Size: 518
    Gene ID
    27301
    NCBI Accession
    NM_014481, NP_055296
    UniProt
    Q9UBZ4
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