TYROBP antibody (Middle Region)

Catalog No. ABIN5515952

Product Details anti-TYROBP Antibody

Target: TYROBP (TYRO Protein tyrosine Kinase Binding Protein (TYROBP))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TYROBP antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: IALAVYFLGR LVPRGRGAAE AATRKQRITE TESPYQELQG QRSDVYSDLN

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TYROBP

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 23 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TYROBP

Target: TYROBP (TYRO Protein tyrosine Kinase Binding Protein (TYROBP))

Alternative Name: TYROBP (TYROBP Products)

Synonyms: TYROBP antibody, DAP12 antibody, tyrpbp antibody, Karap antibody, KARAP antibody, PLOSL antibody, Ly83 antibody, dap12 antibody, TYRO protein tyrosine kinase binding protein antibody, Tyro protein tyrosine kinase binding protein antibody, TYROBP antibody, tyrobp antibody, Tyrobp antibody

Background: This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70 kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene.

Alias Symbols: DAP12, KARAP, PLOSL

Protein Size: 144

Gene ID: 7305

NCBI Accession: NP_001166985

UniProt: K7ES93