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RPE65 antibody (Middle Region)
RPE65
Reactivity: Human
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-RPE65 Antibody
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Target
See all RPE65 Antibodies
RPE65
(Retinal Pigment Epithelium-Specific Protein 65kDa (RPE65))
Binding Specificity
All epitopes for RPE65 antibodies
Middle Region
Reactivity
All reactivities for RPE65 antibodies
Human
Host
All hosts for RPE65 antibodies
Rabbit
Clonality
All clonalities for RPE65 antibodies
Polyclonal
Conjugate
All conjugates for RPE65 antibodies
This RPE65 antibody is un-conjugated
Application
All applications for RPE65 antibodies
Western Blotting (WB)
Sequence
LFKFLSSWSL WGANYMDCFE SNETMGVWLH IADKKRKKYL NNKYRTSPFN
Characteristics
This is a rabbit polyclonal antibody against RPE65. It was validated on Western Blot.
Purification
Affinity Purified
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of Human RPE65
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Discover our top product RPE65 Primary Antibody
Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Target Details for RPE65
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Target
RPE65
(Retinal Pigment Epithelium-Specific Protein 65kDa (RPE65))
Alternative Name
RPE65 (RPE65 Products )
Synonyms
LCA2 antibody, RP20 antibody, mRPE65 antibody, rd12 antibody, sRPE65 antibody, 65kDa antibody, A930029L06Rik antibody, Mord1 antibody, DRPE65 antibody, RPE65 antibody, anon-WO0148162.1 antibody, anon-WO0148163.1 antibody, beta-diox antibody, DmelCG9347 antibody, CG9347 antibody, MGC52887 antibody, MGC154296 antibody, MGC85437 antibody, rpe65 antibody, RPE56c antibody, si:ch211-198n5.12 antibody, 13cIMH antibody, RPE56b antibody, rpepb antibody, si:ch211-198n5.5 antibody, wu:fc74c09 antibody, zgc:110538 antibody, RPE56a antibody, rpepa antibody, zgc:73213 antibody, RPE65, retinoid isomerohydrolase antibody, retinal pigment epithelium 65 antibody, neither inactivation nor afterpotential B antibody, retinal pigment epithelium-specific protein 65kDa S homeolog antibody, retinal pigment epithelium-specific protein 65kDa L homeolog antibody, RPE65 homolog antibody, retinal pigment epithelium-specific protein 65kDa antibody, retinal pigment epithelium-specific protein 65c antibody, retinal pigment epithelium-specific protein 65b antibody, retinal pigment epithelium-specific protein 65a antibody, RPE65 antibody, Rpe65 antibody, ninaB antibody, rpe65.S antibody, rpe65.L antibody, rpe65 antibody, rpe65c antibody, rpe65b antibody, rpe65a antibody
Background
This gene encodes a protein which is located in the retinal pigment epithelium and is involved in the production of 11-cis retinal and in visual pigment regeneration. There are two forms of this protein, a soluble form called sRPE65, and a palmitoylated, membrane-bound form known as mRPE65. mRPE65 serves as the palmitoyl donor for lecithin retinol acyl transferase (LRAT), the enzyme that catalyzes the vitamin A to all trans retinol step of the chromophore regeneration process. Both mRPE65 and sRPE65 also serve as regulatory proteins, with the ratio and concentrations of these molecules playing a role in the inhibition of 11-cis retinal synthesis. Mutations in this gene have been associated with Leber congenital amaurosis type 2 (LCA2) and retinitis pigmentosa. Alias Symbols: RPE65, Protein Interaction Partner: UBC, PSMD13, SLC27A1, RBP4, Protein Size: 533
Gene ID
6121
NCBI Accession
NP_000320
UniProt
Q16518
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