TNRC6B antibody (Middle Region)

Catalog No. ABIN5516264

Product Details anti-TNRC6B Antibody

Target: TNRC6B (Trinucleotide Repeat Containing 6B (TNRC6B))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNRC6B antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: STEWKDPKNT GGWNDYKNNN SSNWGGGRPD EKTPSSWNEN PSKDQGWGGG

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TNRC6B

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TNRC6B

Target: TNRC6B (Trinucleotide Repeat Containing 6B (TNRC6B))

Alternative Name: TNRC6B (TNRC6B Products)

Synonyms: hm:zeh0114 antibody, im:6968518 antibody, wu:fa01f05 antibody, 2700090M07Rik antibody, A730065C02Rik antibody, AI848765 antibody, D230019K20Rik antibody, Cbl27 antibody, trinucleotide repeat containing 6b antibody, trinucleotide repeat containing 6B antibody, trinucleotide repeat containing 6B S homeolog antibody, tnrc6b antibody, TNRC6B antibody, tnrc6b.S antibody, Tnrc6b antibody

Background: Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes.

Protein Size: 1029

Gene ID: 23112

NCBI Accession: NM_001024843, NP_001020014

Pathways: Fc-epsilon Receptor Signaling Pathway, Regulatory RNA Pathways, EGFR Signaling Pathway