CDK2AP1 antibody (Middle Region)

Catalog No. ABIN5516286

Product Details anti-CDK2AP1 Antibody

Target: CDK2AP1 (Cyclin-Dependent Kinase 2 Associated Protein 1 (CDK2AP1))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDK2AP1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: SPSTSMATSS QYRQLLSDYG PPSLGYTQGT GNSQVPQSKY AELLAIIEEL

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human CDK2AP1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CDK2AP1

Target: CDK2AP1 (Cyclin-Dependent Kinase 2 Associated Protein 1 (CDK2AP1))

Alternative Name: CDK2AP1 (CDK2AP1 Products)

Synonyms: MGC64532 antibody, doc1 antibody, st19 antibody, doc-1 antibody, dorc1 antibody, p12doc-1 antibody, Apc10 antibody, Cdkap1 antibody, DORC1 antibody, Doc1 antibody, ST19 antibody, p12 antibody, DOC1 antibody, p12DOC-1 antibody, cyclin-dependent kinase 2 associated protein 1 S homeolog antibody, cyclin dependent kinase 2 associated protein 1 antibody, cyclin dependent kinase 2 associated protein 1 pseudogene antibody, cyclin-dependent kinase 2 associated protein 1 antibody, CDK2 (cyclin-dependent kinase 2)-associated protein 1 antibody, cdk2ap1.S antibody, CDK2AP1 antibody, LOC475806 antibody, cdk2ap1 antibody, Cdk2ap1 antibody

Background: The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Alias Symbols: DOC1, ST19, DORC1, doc-1, p12DOC-1

Protein Size: 115

Gene ID: 8099

NCBI Accession: NM_001270433, NP_001257362

UniProt: O14519