PRSS2 antibody (Middle Region)

Catalog No. ABIN5516528

Product Details anti-PRSS2 Antibody

Target: PRSS2 (Protease, serine, 2 (Trypsin 2) (PRSS2))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRSS2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: EGNEQFINAA KIIRHPKYNS RTLDNDILLI KLSSPAVINS RVSAISLPTA

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PRSS2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PRSS2

Target: PRSS2 (Protease, serine, 2 (Trypsin 2) (PRSS2))

Alternative Name: PRSS2 (PRSS2 Products)

Synonyms: Dvir\\GJ21501 antibody, Dvtry-2 antibody, GJ21501 antibody, Try2 antibody, dvir_GLEANR_6854 antibody, TRY8 antibody, TRYP antibody, Ta antibody, Tesp4 antibody, Ptryss2 antibody, TRY2 antibody, TRYP2 antibody, trypsin-2 antibody, Trypsin-2 antibody, protease, serine 2 antibody, protease, serine, 2 antibody, trypsin II antibody, CpipJ_CPIJ000771 antibody, CpipJ_CPIJ020109 antibody, Dvir\Try2 antibody, Prss2 antibody, PRSS2 antibody, trp-ii antibody

Background: This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.

Alias Symbols: TRY2, TRY8, TRYP2

Protein Size: 247

Gene ID: 5645

NCBI Accession: NM_002770, NP_002761

UniProt: P07478