EYA4 antibody (Middle Region)

Catalog No. ABIN5516718

Product Details anti-EYA4 Antibody

Target: EYA4 (Eyes Absent Homolog 4 (EYA4))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EYA4 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: QESLPGLTNQ PGEFDTMQSP STPIKDLDER TCRSSGSKSR GRGRKNNPSP

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human EYA4

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for EYA4

Target: EYA4 (Eyes Absent Homolog 4 (EYA4))

Alternative Name: EYA4 (EYA4 Products)

Synonyms: B130023L16Rik antibody, CMD1J antibody, DFNA10 antibody, EYA transcriptional coactivator and phosphatase 4 antibody, Eya4 antibody, EYA4 antibody

Background: This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator through its protein phosphatase activity, and it may be important for eye development, and for continued function of the mature organ of Corti. Mutations in this gene are associated with postlingual, progressive, autosomal dominant hearing loss at the deafness, autosomal dominant non-syndromic sensorineural 10 locus. The encoded protein is also a putative oncogene that mediates DNA repair, apoptosis, and innate immunity following DNA damage, cellular damage, and viral attack. Defects in this gene are also associated with dilated cardiomyopathy 1J. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Alias Symbols: CMD1J, DFNA10

Protein Size: 585

Gene ID: 2070

NCBI Accession: NM_001301012, NP_004091

Pathways: Sensory Perception of Sound