HLA-DRB3 antibody (N-Term)

Catalog No. ABIN5516784

Product Details anti-HLA-DRB3 Antibody

Target: HLA-DRB3 (Major Histocompatibility Complex, Class II, DR beta 3 (HLA-DRB3))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HLA-DRB3 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: TLMVLSSRLA FAGDTRPRFL ELRKSECHFF NGTERVRYLD RYFHNQEEFL

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human HLA-DRB3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 16 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for HLA-DRB3

Target: HLA-DRB3 (Major Histocompatibility Complex, Class II, DR beta 3 (HLA-DRB3))

Alternative Name: HLA-DRB3 (HLA-DRB3 Products)

Synonyms: HLA-DR3B antibody, BLA-DRB3 antibody, Bota-DRB01 antibody, Bota-DRB02 antibody, Bota-DRB04 antibody, Bota-DRB07 antibody, Bota-DRB21 antibody, Bota-DRB22 antibody, LA-DRB antibody, major histocompatibility complex, class II, DR beta 3 antibody, major histocompatibility complex, class II, DRB3 antibody, HLA-DRB3 antibody, BOLA-DRB3 antibody

Background: HLA-DRB3 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB3 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.

Alias Symbols: SS1, DRB1, DRw10, HLA-DRB, HLA-DR1B, HLA-DR3B,

Protein Size: 266

Gene ID: 3125

NCBI Accession: NM_022555, NP_072049

UniProt: P79483

Pathways: TCR Signaling, Positive Regulation of Peptide Hormone Secretion, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints