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INSIG1 antibody (Middle Region)

INSIG1 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN5516805
  • Target See all INSIG1 Antibodies
    INSIG1 (Insulin Induced Gene 1 (INSIG1))
    Binding Specificity
    • 7
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Middle Region
    Reactivity
    • 29
    • 8
    • 6
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 29
    Rabbit
    Clonality
    • 29
    Polyclonal
    Conjugate
    • 17
    • 4
    • 2
    • 2
    • 2
    • 2
    This INSIG1 antibody is un-conjugated
    Application
    • 25
    • 17
    • 7
    • 4
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB)
    Sequence
    LAAHGAPDAD PAPRGRSAAM SGPEPGSPYP NTWHHRLLQR SLVLFSVGVV
    Purification
    Affinity purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human INSIG1
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    Discover our top product INSIG1 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 16 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    INSIG1 (Insulin Induced Gene 1 (INSIG1))
    Alternative Name
    INSIG1 (INSIG1 Products)
    Synonyms
    cl-6 antibody, cl6 antibody, CL-6 antibody, CL6 antibody, fb55a03 antibody, fi35b10 antibody, wu:fb55a03 antibody, wu:fi35b10 antibody, zgc:55439 antibody, 1810013C12Rik antibody, Insig-1 antibody, INSIG-1 antibody, insulin induced gene 1 antibody, insulin induced gene 1 L homeolog antibody, INSIG1 antibody, insig1 antibody, insig1.L antibody, Insig1 antibody
    Background
    Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated signaling pathways. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

    Alias Symbols: CL6, CL-6,

    Protein Size: 277
    Gene ID
    3638
    NCBI Accession
    NM_005542, NP_005533
    UniProt
    O15503
    Pathways
    ER-Nucleus Signaling
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