INSIG1 antibody (Middle Region)
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- Target See all INSIG1 Antibodies
- INSIG1 (Insulin Induced Gene 1 (INSIG1))
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Binding Specificity
- Middle Region
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This INSIG1 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- LAAHGAPDAD PAPRGRSAAM SGPEPGSPYP NTWHHRLLQR SLVLFSVGVV
- Purification
- Affinity purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human INSIG1
- Top Product
- Discover our top product INSIG1 Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 16 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- INSIG1 (Insulin Induced Gene 1 (INSIG1))
- Alternative Name
- INSIG1 (INSIG1 Products)
- Synonyms
- cl-6 antibody, cl6 antibody, CL-6 antibody, CL6 antibody, fb55a03 antibody, fi35b10 antibody, wu:fb55a03 antibody, wu:fi35b10 antibody, zgc:55439 antibody, 1810013C12Rik antibody, Insig-1 antibody, INSIG-1 antibody, insulin induced gene 1 antibody, insulin induced gene 1 L homeolog antibody, INSIG1 antibody, insig1 antibody, insig1.L antibody, Insig1 antibody
- Background
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Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated signaling pathways. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Alias Symbols: CL6, CL-6,
Protein Size: 277 - Gene ID
- 3638
- NCBI Accession
- NM_005542, NP_005533
- UniProt
- O15503
- Pathways
- ER-Nucleus Signaling
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