GLCE antibody (Middle Region)

Catalog No. ABIN5516916

Product Details anti-GLCE Antibody

Target: GLCE (Glucuronic Acid Epimerase (GLCE))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GLCE antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: ETAEDRDKNK PNDWTVPKGC FMANVADKSR FTNVKQFIAP ETSEGVSLQL

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human GLCE

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 32 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for GLCE

Target: GLCE (Glucuronic Acid Epimerase (GLCE))

Alternative Name: GLCE (GLCE Products)

Synonyms: HSEPI antibody, RGD1565253 antibody, MGC79110 antibody, 1110017N23Rik antibody, AI747411 antibody, C130034A12Rik antibody, Hsepi antibody, glce antibody, glcel antibody, sb:eu394 antibody, zgc:136701 antibody, glucuronic acid epimerase antibody, glucuronic acid epimerase L homeolog antibody, glucuronyl C5-epimerase antibody, glucuronic acid epimerase b antibody, glucuronic acid epimerase a antibody, GLCE antibody, Glce antibody, glce.L antibody, glce antibody, glceb antibody, glcea antibody

Background: Heparan sulfate (HS) is a negatively charged cell surface polysaccharide required for the biologic activities of circulating extracellular ligands. GLCE is responsible for epimerization of D-glucuronic acid (GlcA) to L-iduronic acid (IdoA) of HS, which endows the nascent polysaccharide chain with the ability to bind growth factors and cytokines (Ghiselli and Agrawal, 2005 [PubMed 15853773])

Alias Symbols: HSEPI,

Protein Size: 617

Gene ID: 26035

NCBI Accession: NM_015554, NP_056369

UniProt: O94923

Pathways: Glycosaminoglycan Metabolic Process