MAML1 antibody (Middle Region)

Catalog No. ABIN5517154

Product Details anti-MAML1 Antibody

Target: MAML1 (Mastermind-Like 1 (MAML1))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAML1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: VNKSSPRPGG PYLQPSHVNL LSHQPPSNLN QNSANNQGSV LDYGNTKPLS

Characteristics: This is a rabbit polyclonal antibody against MAML1. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human MAML1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MAML1

Target: MAML1 (Mastermind-Like 1 (MAML1))

Alternative Name: MAML1 (MAML1 Products)

Synonyms: mam1 antibody, mam-1 antibody, xmam1 antibody, MAML1 antibody, AI644666 antibody, AW743257 antibody, D930008C07Rik antibody, Mam-1 antibody, Mam1 antibody, mKIAA0200 antibody, mastermind like transcriptional coactivator 1 L homeolog antibody, mastermind like transcriptional coactivator 1 antibody, mastermind like 1 (Drosophila) antibody, mastermind-like transcriptional coactivator 1 antibody, maml1.L antibody, MAML1 antibody, Maml1 antibody

Background: This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway.

Alias Symbols: MAML1 {ECO:0000312|HGNC:HGNC:13632

Protein Interaction Partner: Su(H), NOTCH1, RBPJ, PBRM1, PHF8, SMARCA4, HDAC9, PIAS1, MAML1, CDK8, EP300, NOTCH3, NOTCH2, CREBBP, NOTCH4, MAML2, MAML3,

Protein Size: 1016

Gene ID: 9794

NCBI Accession: NP_055572

UniProt: Q92585

Pathways: Notch Signaling, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development