Tescalcin antibody (N-Term)

Catalog No. ABIN5517455

Product Details anti-Tescalcin Antibody

Target: Tescalcin (TESC)

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Tescalcin antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: LELNPIRSKI VRAFFDNRNL RKGPSGLADE INFEDFLTIM SYFRPIDTTM

Characteristics: This is a rabbit polyclonal antibody against TESC. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human TESC

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Tescalcin

Target: Tescalcin (TESC)

Alternative Name: TESC (TESC Products)

Synonyms: TSC antibody, chp3 antibody, CHP3 antibody, 1010001A17Rik antibody, 2410011K10Rik antibody, TE-1 antibody, RGD1566317 antibody, tescalcin antibody, tescalcin L homeolog antibody, tesc antibody, TESC antibody, Tesc antibody, tesc.L antibody

Background: TESC functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. It promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. It promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. It is essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. It is also involved in granulocytic differentiation in a ERK-dependent manner. It inhibits the phosphatase activity of calcineurin.

Alias Symbols: TESC, CHP3,

Protein Interaction Partner: WBP11, UBC, CCDC91, HMG20A, TESC, RAI1, DYNLT3, SLC9A1,

Protein Size: 214

Gene ID: 54997

NCBI Accession: NP_060369

UniProt: Q96BS2

Pathways: Proton Transport