RRAGA antibody (C-Term)

Catalog No. ABIN5517617

Product Details anti-RRAGA Antibody

Target: RRAGA (Ras-Related GTP Binding A (RRAGA))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RRAGA antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: CKEQRDVHRF EKISNIIKQF KLSCSKLAAS FQSMEVRNSN FAAFIDIFTS

Characteristics: This is a rabbit polyclonal antibody against RRAGA. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human RRAGA

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for RRAGA

Target: RRAGA (Ras-Related GTP Binding A (RRAGA))

Alternative Name: RRAGA (RRAGA Products)

Synonyms: FIP-1 antibody, FIP1 antibody, RAGA antibody, 1300010C19Rik antibody, AI255374 antibody, Raga antibody, Ras related GTP binding A antibody, Ras-related GTP binding A antibody, RRAGA antibody, Rraga antibody

Background: RRAGA is a guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. It may play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. Also it may alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death.

Alias Symbols: RRAGA,

Protein Interaction Partner: RRAGC, RPTOR, STAU1, UBC, IL7R, ASAP1, CPSF2, CPSF3, CPSF1, CSTF2T, PAPOLA, CPSF4, CSTF3, CDC73, LAMTOR1, NOL8, RRAGA, RRAGD,

Protein Size: 313

Gene ID: 10670

NCBI Accession: NP_006561

UniProt: Q7L523