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WDR48 antibody (C-Term)

WDR48 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN5517646
  • Target See all WDR48 Antibodies
    WDR48 (WD Repeat Domain 48 (WDR48))
    Binding Specificity
    • 10
    • 10
    • 7
    • 1
    C-Term
    Reactivity
    • 21
    • 4
    • 3
    Human
    Host
    • 22
    Rabbit
    Clonality
    • 22
    Polyclonal
    Conjugate
    • 12
    • 2
    • 2
    • 2
    • 2
    • 2
    This WDR48 antibody is un-conjugated
    Application
    • 20
    • 17
    • 15
    • 13
    • 5
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    NESQTTSSSN NEKPGEQEKE EDIAVLAEEK IELLCQDQVL DPNMDLRTVK
    Purification
    Affinity purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the C terminal region of human WDR48
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    Discover our top product WDR48 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    WDR48 (WD Repeat Domain 48 (WDR48))
    Alternative Name
    WDR48 (WDR48 Products)
    Synonyms
    P80 antibody, UAF1 antibody, 8430408H12Rik antibody, mKIAA1449 antibody, WD repeat domain 48 antibody, WDR48 antibody, Wdr48 antibody
    Background
    Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2, USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. In case of infection by Herpesvirus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein (TIP). Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP. In case of infection by papillomavirus HPV11, promotes the maintenance of the viral genome via its interaction with HPV11 helicase E1.

    Alias Symbols: P80, UAF1, SPG60

    Protein Size: 677
    Gene ID
    57599
    NCBI Accession
    NM_001303402, NP_001290331
    UniProt
    Q8TAF3
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