PIGA antibody (Middle Region)

Catalog No. ABIN5517692

Product Details anti-PIGA Antibody

Target: PIGA (Phosphatidylinositol Glycan Anchor Biosynthesis, Class A (PIGA))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PIGA antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: IICVSYTSKE NTVLRAALNP EIVSVIPNAV DPTDFTPDPF RRHDSITIVV

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PIGA

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PIGA

Target: PIGA (Phosphatidylinositol Glycan Anchor Biosynthesis, Class A (PIGA))

Alternative Name: PIGA (PIGA Products)

Synonyms: GPI3 antibody, MCAHS2 antibody, PIG-A antibody, AI194334 antibody, Pig-a antibody, im:6911675 antibody, zgc:56589 antibody, phosphatidylinositol glycan anchor biosynthesis class A antibody, phosphatidylinositol glycan anchor biosynthesis, class A antibody, PIGA antibody, Piga antibody, piga antibody

Background: This gene encodes a protein required for synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the biosynthetic pathway of GPI anchor. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. Paroxysmal nocturnal hemoglobinuria, an acquired hematologic disorder, has been shown to result from mutations in this gene. Alternate splice variants have been characterized. A related pseudogene is located on chromosome 12.

Alias Symbols: GPI3, PNH1, PIG-A, MCAHS2

Protein Size: 484

Gene ID: 5277

NCBI Accession: NM_002641, NP_002632

UniProt: P37287

Pathways: Inositol Metabolic Process