REV1 antibody (C-Term)

Catalog No. ABIN5517785

Product Details anti-REV1 Antibody

Target: REV1 (REV1, Polymerase (DNA Directed) (REV1))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This REV1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: INLIALPAFS QVDPEVFAAL PAELQRELKA AYDQRQRQGE NSTHQQSASA

Characteristics: This is a rabbit polyclonal antibody against REV1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human REV1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for REV1

Target: REV1 (REV1, Polymerase (DNA Directed) (REV1))

Alternative Name: REV1 (REV1 Products)

Synonyms: ARABIDOPSIS THALIANA HOMOLOG OF REVERSIONLESS 1 antibody, ATREV1 antibody, K23L20.9 antibody, K23L20_9 antibody, 1110027I23Rik antibody, AU022044 antibody, Rev1l antibody, REV1L antibody, DNA-directed DNA polymerase antibody, HIG1 hypoxia inducible domain family member 1C antibody, REV1, DNA directed polymerase antibody, REV1 antibody, HIGD1C antibody, Rev1 antibody

Background: This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. Two alternatively spliced transcript variants that encode different proteins have been found.

Alias Symbols: REV1, REV1L,

Protein Interaction Partner: RELA, POLD3, MSH2, REV3L, BRCA1, PCNA, MAD2L2, POLH, UBC, CDC27, REV1, POLK, POLI, C1orf86, MYC, HSP90AB1, HSP90AA1, POLDIP2, POLL, FHL2,

Protein Size: 1251

Gene ID: 51455

NCBI Accession: XP_005264024

UniProt: Q9UBZ9

Pathways: DNA Damage Repair, Regulation of Actin Filament Polymerization, Production of Molecular Mediator of Immune Response