ENY2 antibody (N-Term)

Catalog No. ABIN5517911

Product Details anti-ENY2 Antibody

Target: ENY2 (Enhancer of Yellow 2 Homolog (ENY2))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ENY2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: QMRAAINQKL IETGERERLK ELLRAKLIEC GWKDQLKAHC KEVIKEKGLE

Characteristics: This is a rabbit polyclonal antibody against ENY2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human ENY2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ENY2

Target: ENY2 (Enhancer of Yellow 2 Homolog (ENY2))

Alternative Name: ENY2 (ENY2 Products)

Synonyms: e(y)2 antibody, 1810057B09Rik antibody, 6720481I12 antibody, DC6 antibody, Ey2 antibody, zgc:92656 antibody, enhancer of yellow 2 homolog L homeolog antibody, ENY2, transcription and export complex 2 subunit antibody, enhancer of yellow 2 homolog (Drosophila) antibody, eny2.L antibody, ENY2 antibody, Eny2 antibody, eny2 antibody

Background: ENY2 is involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. It is required for nuclear receptor-mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.

Alias Symbols: ENY2, DC6,

Protein Interaction Partner: UBC, CIAPIN1, APP, ATXN7, USP22, MCM3AP, ATXN7L3, TRRAP, TAF10, KAT2A,

Protein Size: 101

Gene ID: 56943

NCBI Accession: NP_064574

UniProt: Q9NPA8