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APEX2 antibody (AA 102-210)

APEX2 Reactivity: Rat WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN5518737
  • Target See all APEX2 Antibodies
    APEX2 (APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2))
    Binding Specificity
    • 15
    • 7
    • 6
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 102-210
    Reactivity
    • 21
    • 15
    • 15
    Rat
    Host
    • 34
    • 2
    Rabbit
    Clonality
    • 36
    Polyclonal
    Conjugate
    • 12
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This APEX2 antibody is un-conjugated
    Application
    • 34
    • 17
    • 15
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Purpose
    Rabbit IgG polyclonal antibody for DNA-(apurinic or apyrimidinic site) lyase 2(APEX2) detection. Tested with WB in Human,Rat.
    Cross-Reactivity (Details)
    Predicted Cross Reactivity: human
    No cross reactivity with other proteins.
    Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.
    Characteristics
    Rabbit IgG polyclonal antibody for DNA-(apurinic or apyrimidinic site) lyase 2(APEX2) detection. Tested with WB in Human,Rat.
    Gene Name: APEX nuclease (apurinic/apyrimidinic endonuclease) 2
    Protein Name: DNA-(apurinic or apyrimidinic site) lyase 2
    Purification
    Immunogen affinity purified.
    Immunogen
    E.coli-derived human APEX2 recombinant protein (Position: L102-A210). Human APEX2 shares 91.7% amino acid (aa) sequence identity with mouse APEX2.
    Isotype
    IgG
    Top Product
    Discover our top product APEX2 Primary Antibody
  • Application Notes
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Rat, Predicted Species: Human
    Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
    Other applications have not been tested. Optimal dilutions should be determined by end users.
    Comment

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Concentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • Target
    APEX2 (APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2))
    Alternative Name
    APEX2 (APEX2 Products)
    Synonyms
    APE2 antibody, APEXL2 antibody, XTH2 antibody, ape2 antibody, apexl2 antibody, xth2 antibody, zgc:55889 antibody, C430040P13Rik antibody, apurinic/apyrimidinic endodeoxyribonuclease 2 antibody, APEX nuclease (apurinic/apyrimidinic endonuclease) 2 antibody, apurinic/apyrimidinic endodeoxyribonuclease 2 L homeolog antibody, apurinic/apyrimidinic endonuclease 2 antibody, APEX2 antibody, apex2 antibody, apex2.L antibody, Apex2 antibody
    Background
    APEX2, also called apurinic/apyrimidinic endonuclease like-2, is a member of the apurinic/apyrimidinic (AP) family of endonucleases that initiate the repair of AP sites formed by spontaneous hydrolysis of the N-glycosylic bond, mutagen-induced base release, or damaged-base excision by a DNA repair glycosylase. RT-PCR detected APEX2 expression in HeLa cells, Jurkat cells, and human kidney, brain and fetal brain tissue. The APEX2 gene is mapped to chromosome Xp11.21. APEX2 participates in both nuclear and mitochondrial base excision repair (BER) and it can play a role in processing 3-prime-damaged termini or 3-prime-mismatched nucleotides. Additionally, APEX2 displayed weaker AP site-specific and 3-prime nuclease activities compared to APEX1.

    Synonyms: AP endonuclease XTH2 | APE2 | APE2 | XTH2 | APEX nuclease-like 2 | APEX2 | APEXL 2 | APEXL2 | Q9UBZ4 | XTH 2
    Gene ID
    27301
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