MC1 Receptor antibody (C-Term)

Catalog No. ABIN5518773

Product Details anti-MC1 Receptor Antibody

Target: MC1 Receptor (MC1R) (Melanocortin 1 Receptor (MC1R))

Binding Specificity: AA 290-317, C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MC1 Receptor antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: Rabbit IgG polyclonal antibody for Melanocyte-stimulating hormone receptor(MC1R) detection. Tested with WB in Human,Mouse,Rat.

Sequence: NAIIDPLIYA FHSQELRRTL KEVLTCSW

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for Melanocyte-stimulating hormone receptor(MC1R) detection. Tested with WB in Human,Mouse,Rat.
Gene Name: melanocortin 1 receptor
Protein Name: Melanocyte-stimulating hormone receptor

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human MC1 Receptor (290-317aa NAIIDPLIYAFHSQELRRTLKEVLTCSW).

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Target Details for MC1 Receptor

Target: MC1 Receptor (MC1R) (Melanocortin 1 Receptor (MC1R))

Alternative Name: MC1R (MC1R Products)

Synonyms: CMM5 antibody, MSH-R antibody, SHEP2 antibody, Mshra antibody, Tob antibody, e antibody, MC1-R antibody, MSHR antibody, mc1r antibody, MC1R antibody, TUBB3 antibody, melanocortin 1 receptor antibody, melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) antibody, MC1R antibody, Mc1r antibody, mc1r antibody, mc1r_par1 antibody

Background: The melanocortin 1 receptor (MC1R), mapped to 16q24.3, is also known as MSHR. This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.

Synonyms: CMM5 | MC1-R | MC1R | MSH-R | MSHR | SHEP2 | Q01726

Gene ID: 4157

UniProt: Q01726

Pathways: cAMP Metabolic Process, Feeding Behaviour